The impact of diabetology consultations on length of stay in hospitalized patients with diabetes.

Introduction: Both hyperglycaemia and hypoglycaemia in hospitalized patients have been shown to be associated with a longer length of stay, higher readmission rates, and higher rates of morbidity and mortality. With 25%-30% of all hospitalized patients carrying a diagnosis of diabetes, it is important to optimize glycaemic control. Current guidelines for care of inpatients with diabetes now suggest consulting a specialized diabetes team for all patients when possible.

Pleiotropic effects of thiazolidinediones: implications for the treatment of patients with type 2 diabetes mellitus.

Thiazolidinediones (TZDs) are insulin-sensitizing antidiabetes agents that act through the peroxisome proliferator-activated receptor-γ to cause a durable improvement in glycemic control in patients with type 2 diabetes mellitus. Although less well recognized, TZDs also exert a protective effect on β-cell function. In addition to their beneficial effects on glucose homeostasis, TZDs-especially pioglitazone-exert a number of other pleiotropic effects that make them ideal agents as monotherapy or in combination with other oral agents, glucagon-like peptide-1 analogs, or insulin.

Increased tissue-type plasminogen activator: a facade in the fibrinolytic system in type 2 diabetes.

Unlabelled: To determine whether the increased concentration in blood of total tissue-type plasminogen activator (t-PA), accompanying increased plasminogen activator inhibitor type-1 (PAI-1) seen with diabetes reflects increased free t-PA and hence activity or simply increased t-PA complexed with PAI-1, we measured each in 39 people with type 2 diabetes. The increased total t-PA occurred in the absence of an increase in t-PA activity detectable in venous blood samples despite the increase in the concentration of total t-PA protein.

Background: Type 2 diabetes is known to be associated with increased concentrations in blood of total tissue-type plasminogen activator (t-PA) [free t-PA plus t-PA complexed with plasminogen activator inhibitor type-1 (PAI-1)] and PAI-1.

The community ecology of diabetes patient classification and practice characteristics.

We examined the clinical and epidemiologic characteristics of diabetic subjects ascertained from five different sources (hospital, private practice, specialist practice, nursing home, and prevalence survey) in a medium-sized upstate New York community. Patients were categorized using the National Diabetes Data Group classification (based on weight and insulin requirement) and using an alternative clinical classification scheme based on age at onset and insulin use. Both classifications demonstrate marked differences in the distribution of diabetic subjects.