Publications by authors named "J J Schnitzer"
Article Synopsis
- The study investigates the effects of different doses of bleomycin in a mouse model to understand lung fibrosis, examining various health outcomes over a 14-day period.
- It was found that doses between 0.25-0.5 U/kg led to significant weight loss and increased pulmonary inflammation, while 3 U/kg caused 100% mortality.
- Lower doses (0.1 U/kg) resulted in mild changes, indicating that certain doses can induce noticeable fibrotic changes without causing death, making them ideal for further research.
Article Synopsis
- Modern medicine aims to enhance treatment effectiveness while minimizing side effects, with nanoparticles (NPs) offering promising potential for targeted drug delivery and imaging.
- However, the small size of NPs often leads to quick removal from the bloodstream and limited effectiveness due to challenges in crossing important cell barriers.
- This research demonstrates a method to exploit endothelial caveolae in the lungs to improve NP delivery, achieving higher lung concentrations than in the bloodstream, which could enhance both diagnostics and therapies in future medical applications.
Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease characterized by the relentless deposition of extracellular matrix (ECM), causing lung distortions and dysfunction. Animal models of human IPF can provide great insight into the mechanistic pathways underlying disease progression and a means for evaluating novel therapeutic approaches. In this study, we describe the effect of bleomycin concentration on disease progression in the classical rat bleomycin model.
View Article and Find Full Text PDFLarge immune complexes formed by the cross-linking of antibodies with polyvalent antigens play critical roles in modulating cell-mediated immunity. While both the size and the shape of immune complexes are important determinants in Fc receptor-mediated signaling responsible for phagocytosis, degranulation, and, in some instances, autoimmune pathologies, their characterization remains extremely challenging due to their large size and structural heterogeneity. We use native mass spectrometry (MS) supplemented with limited charge reduction in the gas phase to determine the stoichiometry of immune complexes formed by a bivalent (homodimeric) antigen, a 163 kDa aminopeptidase P2 (APP2), and a monoclonal antibody (mAb) to APP2.
View Article and Find Full Text PDFIntroduction: We investigated the potential of LPS (10-300 µg/rat) administered intratracheally (i.t.) to induce reproducible features of acute lung injury (ALI) and compared the pharmacological efficacy of anti-inflammatory glucocorticoids and antifibrotic drugs to reduce the disease.
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