ML-EM based dual tracer PET image reconstruction with inclusion of prompt gamma attenuation.

Conventionally, if two metabolic processes are of interest for image analysis, two separate, sequential positron emission tomography (PET) scans are performed. However, sequential PET scans cannot simultaneously display the metabolic targets. The concurrent study of two simultaneous PET scans could provide new insights into the causes of diseases.

Impact of improved dead time correction on the quantification accuracy of a dedicated BrainPET scanner.

Objective: Quantitative values derived from PET brain images are of high interest for neuroscientific applications. Insufficient DT correction (DTC) can lead to a systematic bias of the output parameters obtained by a detailed analysis of the time activity curves (TACs). The DTC method currently used for the Siemens 3T MR BrainPET insert is global, i.

Setup and characterisation according to NEMA NU 4 of thePET scanner, a PET system dedicated for plant sciences.

ThePET system is a plant dedicated positron emission tomography (PET) scanner consisting of fully digital photo multipliers with lutetium-yttrium oxyorthosilicate crystals and located inside a custom climate chamber. Here, we present the setup ofPET, its data processing and image reconstruction together with its performance.The performance characterization follows the national electrical manufacturers association (NEMA) standard for small animal PET systems with a number of adoptions due to the vertical oriented bore of a PET for plant sciences.

Assessment of Brain Tumour Perfusion Using Early-Phase F-FET PET: Comparison with Perfusion-Weighted MRI.

Purpose: Morphological imaging using MRI is essential for brain tumour diagnostics. Dynamic susceptibility contrast (DSC) perfusion-weighted MRI (PWI), as well as amino acid PET, may provide additional information in ambiguous cases. Since PWI is often unavailable in patients referred for amino acid PET, we explored whether maps of relative cerebral blood volume (rCBV) in brain tumours can be extracted from the early phase of PET using O-(2-F-fluoroethyl)-L-tyrosine (F-FET).

GABA receptor availability relates to emotion-induced BOLD responses in the medial prefrontal cortex: simultaneous fMRI/PET with [C]flumazenil.

Introduction: The fMRI BOLD response to emotional stimuli highlighting the role of the medial prefrontal cortex (MPFC) has been thoroughly investigated. Recently, the relationship between emotion processing and GABA levels has been studied using MPFC proton magnetic resonance spectroscopy (1H-MRS). However, the role of GABAA receptors in the MPFC during emotion processing remains unexplored.