Publications by authors named "J J SACCO"
Article Synopsis
- The study investigates how the methyltransferase EZH2 is influenced by both chemical signals like TGF-β1 and mechanical signals from stiff environments, impacting gene expression and potentially advancing cancer and fibrosis.
- Cells cultured on stiff surfaces along with TGF-β1 show increased EZH2 movement to the nucleus and higher levels of a specific histone modification (H3K27me3), which is crucial for regulating gene expression and inducing changes linked to epithelial-mesenchymal transition (EMT).
- The research suggests that the activity of EZH2 relies on cellular contractility pathways involving Rho-associated kinase (ROCK) and myosin II, highlighting a way that stiffness and TGF-β1 work together to
Epithelial-Mesenchymal Plasticity and Epigenetic Heterogeneity in Cancer.
Cancers (Basel)
September 2024
The tumor microenvironment comprises various cell types and experiences dynamic alterations in physical and mechanical properties as cancer progresses. Intratumoral heterogeneity is associated with poor prognosis and poses therapeutic challenges, and recent studies have begun to identify the cellular mechanisms that contribute to phenotypic diversity within tumors. This review will describe epithelial-mesenchymal (E/M) plasticity and its contribution to phenotypic heterogeneity in tumors as well as how epigenetic factors, such as histone modifications, histone modifying enzymes, DNA methylation, and chromatin remodeling, regulate and maintain E/M phenotypes.
View Article and Find Full Text PDFThe 2023 Cure Ocular Melanoma (CURE OM) Global Science Meeting was held in Philadelphia on November 6, 2023. There is increased awareness and dedicated research in uveal melanoma (UM), but unmet needs remain in the prevention, detection, and treatment of UM. The purpose of this meeting was to provide an international forum for the exchange of research ideas, to allow for discussion of basic science as well as clinical research on UM, and to gather input about advocacy and patient needs.
View Article and Find Full Text PDFBackground: Pre-clinical studies suggest AZD1775, a WEE1 kinase inhibitor, potentiates the activity of various chemotherapeutic agents.
Methods: WISTERIA was a prospective, parallel two-group, open-label, dose-finding, phase I clinical trial. Eligible patients had histologically confirmed oral, laryngeal, or hypopharyngeal squamous cell carcinoma, ECOG performance status 0/1, and aged ≥18-to-≤70 years.
Purpose: To present a novel technique of preperitoneal cross-over for eTEP VHR.
Methods: Patients who underwent robotic eTEP with mesh utilizing a preperitoneal cross over technique were identified using a single-institution hernia database. This novel technique involves minimally invasive access to the retro-rectus space on one side with midline cross over into the preperitoneal space on the contralateral side.