Publications by authors named "J J Ramsden"
Article Synopsis
- Saturated heterocycles are important for drug development but are difficult to synthesize, especially in an asymmetric manner.* -
- The study illustrates the use of imine reductases in tandem processes to create these heterocycles through both inter- and intramolecular reductive amination.* -
- The approach enables the production of various unsubstituted and substituted heterocycles from simple materials in a single reaction under mild conditions, showcasing the versatility of imine reductases.*
This study investigated the extent of injury incidence and burden in a professional women football team of the Scottish Women's Premier League during two seasons. All injuries causing time-loss or required medical attention were recorded prospectively. A total of 671 injuries, 570 requiring medical attention and 101 causing time-loss were recorded in 41 players.
View Article and Find Full Text PDFProximie in the operating theatre: evaluation of a virtual operating platform for medical student education.
Ann R Coll Surg Engl
November 2024
Introduction: Medical students often hesitate to enter the operating theatre because of poor visibility of the surgical field and anxiety about the theatre environment. In addition, ear, nose and throat (ENT) surgery is underrepresented in many medical curricula. Virtual systems like Proximie offer flexible viewing of surgeries with surgeon commentary, potentially addressing these issues.
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- Crouzon syndrome with acanthosis nigricans (CAN) results from a specific genetic mutation and is characterized by craniosynostosis, midface hypoplasia, and hyperkeratotic skin disorders.
- A study reviewed six patients diagnosed with CAN over 36 years, examining their medical histories and challenges related to speech, language, hearing, and feeding.
- Findings indicated that all patients experienced significant complications such as airway management needs, feeding difficulties, and hearing loss, with common issues including low weight and communication disorders.
Purpose: During the course of demyelinating inflammatory diseases, myelin-derived proteins, including myelin basic protein(MBP), are secreted into extracellular space. MBP shows extensive post-translational modifications, including deimination/citrullination. Deiminated MBP is structurally less ordered, susceptible to proteolytic attack, and more immunogenic than unmodified MBP.
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