3D deuterium metabolic imaging (DMI) of the human liver at 7 T using low-rank and subspace model-based reconstruction.

Purpose: To implement a low-rank and subspace model-based reconstruction for 3D deuterium metabolic imaging (DMI) and compare its performance against Fourier transform-based (FFT) reconstruction in terms of spectral fitting reliability.

Methods: Both reconstruction methods were applied on simulated and experimental DMI data. Numerical simulations were performed to evaluate the effect of increasing acceleration factors.

Human Brain Deuterium Metabolic Imaging at 7 T: Impact of Different [6,6'-H]Glucose Doses.

Background: Deuterium metabolic imaging (DMI) is an innovative, noninvasive metabolic MR imaging method conducted after administration of H-labeled substrates. DMI after [6,6'-H]glucose consumption has been used to investigate brain metabolic processes, but the impact of different [6,6'-H]glucose doses on DMI brain data is not well known.

Purpose: To investigate three different [6,6'-H]glucose doses for DMI in the human brain at 7 T.

Indirect H-[C] MRS of the human brain at 7 T using a C-birdcage coil and eight transmit-receive H-dipole antennas with a 32-channel H-receive array.

The neuronal tricarboxylic acid and glutamate/glutamine (Glu/Gln) cycles play important roles in brain function. These processes can be measured in vivo using dynamic H-[C] MRS during administration of C-labeled glucose. Proton-observed carbon-edited (POCE) MRS enhances the signal-to-noise ratio (SNR) compared with direct C-MRS.

Measurement of metabolite levels and treatment-induced changes in hepatic metastases of gastro-esophageal cancer using 7-T phosphorus magnetic resonance spectroscopic imaging.

Methods for early treatment response evaluation to systemic therapy of liver metastases are lacking. Tumor tissue often exhibits an increased ratio of phosphomonoesters to phosphodiesters (PME/PDE), which can be noninvasively measured by phosphorus magnetic resonance spectroscopy (P MRS), and may be a marker for early therapy response assessment in liver metastases. However, with commonly used P surface coils for liver P MRS, the liver is not fully covered, and metastases may be missed.

P MR Spectroscopy in the Pancreas: Repeatability, Comparison With Liver, and Pilot Pancreatic Cancer Data.

Background: Non-invasive evaluation of phosphomonoesters (PMEs) and phosphodiesters (PDEs) by 31-phosphorus MR spectroscopy (P MRS) may have potential for early therapy (non-)response assessment in cancer. However, P MRS has not yet been applied to investigate the human pancreas in vivo.

Purpose: To assess the technical feasibility and repeatability of P MR spectroscopic imaging (MRSI) of the pancreas, compare P metabolite levels between pancreas and liver, and determine the feasibility of P MRSI in pancreatic cancer.