Publications by authors named "J J Presa"
Background: The morbidity and mortality associated with influenza viruses are a significant public health challenge. Annual vaccination against circulating influenza strains reduces hospitalisations and increases survival rates but requires a yearly redesign of vaccines against prevalent subtypes. The complex genetics of influenza viruses with high antigenic drift create an ongoing challenge in vaccine development to address dynamic influenza epidemiology.
View Article and Find Full Text PDFIntroduction: The most frequently used first-line treatment in patients with advanced hepatocellular carcinoma (HCC) is atezolizumab plus bevacizumab. Upon progression after this treatment, the standard of care in many countries is sorafenib, due to the lack of reimbursement for other drugs. Several randomized trials are currently underway to clarify the best second-line therapy in patients with HCC.
View Article and Find Full Text PDFArticle Synopsis
- Researchers aimed to evaluate spleen stiffness measurement (SSM) as a standalone non-invasive test for clinically significant portal hypertension (CSPH) in patients with compensated advanced chronic liver disease (cACLD) and compare it to the existing ANTICIPATE±NASH model.
- The study involved 407 patients recruited from 16 expert centers in Europe, utilizing various non-invasive tests alongside hepatic venous pressure gradient measurements to assess CSPH probability.
- The findings indicated the potential for SSM to enhance diagnostic capabilities, as models were created to evaluate its effectiveness and discriminative ability compared to existing methods using binary logistic regression analysis.
Article Synopsis
- * A retrospective analysis of 885 HCC patients showed no significant differences in overall survival, time to progression, or disease control rates between viral and nonviral patients treated with the combination therapy.
- * Common prognostic factors were identified across both groups, but there might be some stronger associations between immunological factors and outcomes specifically in viral patients, while treatment-related toxicities and second-line treatments showed nearly identical results for both etiology subgroups.
Article Synopsis
- Low Vaccination Rates
- : The text discusses the low uptake of meningococcal vaccines in the US and emphasizes the importance of understanding factors influencing vaccination preferences to potentially increase these rates.
- Study Design and Findings
- : A study was conducted with adolescents and their guardians to assess their willingness to vaccinate based on various vaccine attributes, highlighting that 59.5% of participants favored vaccination regardless of the attributes presented.
- Key Influencing Factors
- : The findings revealed that the key factors affecting vaccination choice were the vaccine's level of protection and the likelihood of mild-to-moderate side effects, with a new pentavalent vaccine option further boosting willingness among specific demographics.