Survival probabilities of thornback skate (Raja clavata) and spotted skate (Raja montagui) discarded by tickler chain beam trawl, pulse trawl, and flyshoot fisheries.

We measured discards survival probabilities of thornback (Raja clavata) and spotted skate (Raja montagui) in tickler chain beam trawling (5 trips, n = 183 for thornback skate, n = 137 for spotted skate), pulse beam trawling (9 trips, n = 94 for thornback skate) and flyshoot fishieres (4 trips, n = 137 for thornback skate, n = 24 for spotted skate). Survival probabilities were measured by captive observation for 15 to 25 days post catch. All fishery operations were conducted in the southern North Sea (ICES division 27.

Neuropsychological Profiles in Genetic Frontotemporal Dementia: A Meta-Analysis and Systematic Review.

Characterization of cognitive profiles across genetic FTD gene mutations is crucial for the identification of sensitive endpoints for clinical trials targeting specific pathologies. However, no systematic overview of the literature describing cognitive profiles in different FTD gene mutations has been made thus far. We performed a meta-analysis and systematic review to characterize cognitive profiles across the different FTD gene mutations and clinical disease stages of familial frontotemporal dementia (FTD).

Impairments in knowledge of social norms in presymptomatic, prodromal, and symptomatic frontotemporal dementia.

Introduction: We aimed to assess the knowledge of social norms in patients with behavioral variant frontotemporal dementia (bvFTD) with the Dutch version of the Social Norms Questionnaire (SNQ-NL).

Methods: The SNQ-NL was administered in 34 patients with bvFTD, 20 prodromal mutation carriers, 76 presymptomatic mutation carriers, and 56 controls. Group differences and correlations with other neuropsychological tests and gray matter volume were examined.

Occupational differences in a Dutch sample of patients with primary progressive aphasia, behavioral variant frontotemporal dementia, and Alzheimer's dementia.

Background: Cognitive reserve is a potential mechanism to cope with brain damage as a result of dementia, which can be defined by indirect proxies, including education level, leisure time activities, and occupational attainment. In this study we explored the association between dementia diagnosis and type of occupation in a retrospective Dutch outpatient memory clinic sample of patients with primary progressive aphasia (PPA), behavioral variant frontotemporal dementia (bvFTD), and Alzheimer's Dementia (AD).

Methods: We included data from 427 patients (bvFTD  = 87, PPA  = 148, AD  = 192) and compared the frequency of occupations (11 categories) between patients and data from the Dutch census using Pearson tests and we calculated odds ratios (OR) by means of multinomial logistic regression analyses.

Distinctive cell-free DNA methylation characterizes presymptomatic genetic frontotemporal dementia.

Objective: Methylation of plasma cell-free DNA (cfDNA) has potential as a marker of brain damage in neurodegenerative diseases such as frontotemporal dementia (FTD). Here, we study methylation of cfDNA in presymptomatic and symptomatic carriers of genetic FTD pathogenic variants, next to healthy controls.

Methods: cfDNA was isolated from cross-sectional plasma of 10 presymptomatic carriers (4 C9orf72, 4 GRN, and 2 MAPT), 10 symptomatic carriers (4 C9orf72, 4 GRN, and 2 MAPT), and 9 healthy controls.