Publications by authors named "J J Poole"
Background: Physical function is a key determinant of independence among older adults. Yet, there are barriers to assessing physical function in clinic. We developed a wearable geriatric functional assessment system (GFAS) that quickly and effortlessly evaluates physical function.
View Article and Find Full Text PDFObjective: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a significant cause of morbidity and mortality among patients with RA, yet effective risk stratification for RA-ILD is lacking. We sought to characterize unique peripheral blood biomarker signatures in RA that could improve RA-ILD discrimination beyond clinical and genetic risk factors.
Methods: We performed a cross-sectional study of participants in the Veterans Affairs Rheumatoid Arthritis (VARA) registry.
Importance: Alternating hemiplegia of childhood (AHC) is a disorder that can result from pathogenic variants in ATP1A3-encoded sodium-potassium adenosine triphosphatase alpha 3 (ATP1A3). While AHC is primarily a neurologic disease, some individuals experience sudden unexplained death (SUD) potentially associated with cardiac arrhythmias.
Objective: To determine the impact of ATP1A3 variants on cardiac electrophysiology and whether lethal ventricular arrhythmias are associated with SUD in patients with AHC.
Article Synopsis
- The study investigates the potential of interleukin-10 (IL-10) therapy to treat lung inflammation caused by repeated exposure to lipopolysaccharide (LPS) in mice.
- IL-10 treatment effectively reduced various inflammatory markers, weight loss, and lung cell infiltration, showing less airway hyperresponsiveness and improved lung function.
- Results suggest that delivering IL-10 directly to the lungs can significantly mitigate inflammation and repair processes in response to harmful environmental agents.