Advantages and Challenges of Using Antimicrobial Peptides in Synergism with Antibiotics for Treating Multidrug-Resistant Bacteria.

Multidrug-resistant bacteria (MDR) have become a global threat, impairing positive outcomes in many cases of infectious diseases. Treating bacterial infections with antibiotic monotherapy has become a huge challenge in modern medicine. Although conventional antibiotics can be efficient against many bacteria, there is still a need to develop antimicrobial agents that act against MDR bacteria.

Small and Versatile Cyclotides as Anti-infective Agents.

Plants provide an abundant source of potential therapeutic agents, including a diverse array of compounds, such as cyclotides, which are peptides known for their antimicrobial activity. Cyclotides are multifaceted molecules with a wide range of biological activities. Their unique topology forms a head-to-tail cyclic structure reinforced by a cysteine knot, which confers chemical and thermal stability.

Bayesian spatio-temporal modeling of severe acute respiratory syndrome in Brazil: A comparative analysis across pre-, during, and post-COVID-19 eras.

This paper presents an investigation into the spatio-temporal dynamics of Severe Acute Respiratory Syndrome (SARS) across the diverse health regions of Brazil from 2016 to 2024. Leveraging extensive datasets that include SARS cases, climate data, hospitalization records, and COVID-19 vaccination information, our study employs a Bayesian spatio-temporal generalized linear model to capture the intricate dependencies inherent in the dataset. The analysis reveals significant variations in the incidence of SARS cases over time, particularly during and between the distinct eras of pre-COVID-19, during, and post-COVID-19.

Inclusion of cross-cultural care training in humanitarian aid: A scoping review.

Objectives: Cross-cultural care creates environments where people from diverse cultural backgrounds can access healthcare without facing discrimination based on their beliefs or identity. Humanitarian aid workers need the knowledge and skills to effectively address the needs of diverse populations. In humanitarian aid, cross-cultural care training is crucial for delivering culturally sensitive healthcare in challenging environments.

Thermally Activated Delayed Fluorescence in B,N-Substituted Tetracene Derivatives: A Theoretical Pathway to Enhanced OLED Materials.

Polycyclic aromatic hydrocarbons (PAHs) exhibit intriguing characteristics that position them as promising candidates for advancements in organic semiconductor technologies. Notably, tetracene finds substantial utility in Electronics due to its application in organic light-emitting diodes (OLEDs) and organic field-effect transistors (OFETs). The strategic introduction of an isoelectronic boron-nitrogen (B,N) pair to replace a carbon-carbon pair in acenes introduces changes in the electronic structure, allowing for the controlled modulation of diradical characteristics.