Publications by authors named "J J Paulin"
Molecular Docking and Pharmacokinetic Profiling of Nab-paclitaxel as Advanced Chemotherapeutic Agent Against HER-2 Positive Breast Cancer Patients.
Asian Pac J Cancer Prev
October 2024
Objective: The main objective of the study is to explore the potential molecular benefits of Nab-paclitaxel as an effective advanced chemotherapeutic agent for HER2-positive breast cancer patients. Specifically, the study aims to assess Nab-paclitaxel as a potential drug candidate for breast cancer treatment.
Methods: This study used bioinformatics and cheminformatics to analyze the HER2 signaling pathway and its possible interactions with Nab-Paclitaxel.
Background: Violence against Emergency Medical Services (EMS) personnel vary between studies. Current studies are mainly based on self-reporting, thus other designs are needed to provide more perspective. The purpose of this study was to explore the rate and predictors of violent behavior targeted at EMS personnel by exploring the Electronic patient care records (ePCR) documentation by EMS personnel.
View Article and Find Full Text PDFArticle Synopsis
- Plantar hyperhidrosis (PHH) significantly affects psychosocial well-being, and endoscopic lumbar sympathectomy (ELS) is considered the best treatment option, despite concerns about compensatory sweating and sexual effects, especially in men.
- A study involving male patients who underwent ELS from 2014-2022 assessed the long-term effectiveness of the procedure and any postoperative side effects through remote interviews and standardized questionnaires.
- Results showed that 80% of patients achieved significant sweat reduction, with most reporting minimal issues related to compensatory sweating and no cases of erectile dysfunction, leading to improved quality of life and overall satisfaction with the surgery.
This study sought to investigate if heterosexual-couple parents with adolescent children following identity-release oocyte donation (OD), sperm donation (SD) or standard IVF differed with regard to psychological distress, family functioning, and parent-child relationships. The prospective longitudinal Swedish Study on Gamete Donation consists of couples recruited when starting treatment between 2005 and 2008 from seven Swedish university hospitals providing gamete donation. This study concerns the fifth wave of data collection and included a total of 205 mothers and fathers with adolescent children following OD ( = 73), SD ( = 67), or IVF with own gametes ( = 65).
View Article and Find Full Text PDFArticle Synopsis
- The study examined the clinical features and outcomes of 349 dogs in Saskatchewan diagnosed with anticoagulant rodenticide (AR) intoxication between 1999 and 2022.
- Most cases occurred in the warmer months (July-October), with a majority of dogs coming from urban areas and primarily ingesting second-generation rodenticides, particularly bromadiolone.
- Clinical signs such as lethargy, dyspnea, and hemorrhage were noted, and dogs that received blood products showed significantly better survival rates, with 86% of those with AR-induced hemorrhage surviving to discharge.