Publications by authors named "J J P Bogaards"
Multicenter Evaluation of Memory Remediation in Traumatic Brain Injury With Donepezil: A Randomized Controlled Trial.
J Neuropsychiatry Clin Neurosci
December 2024
Article Synopsis
- Memory impairments are a common issue after traumatic brain injury (TBI), and donepezil, a medication that helps with cognitive function, was evaluated for its effectiveness on these memory problems in a clinical trial called MEMRI-TBI-D.
- The study involved 75 participants with severe memory issues related to TBI, who were split into two groups: one receiving donepezil and the other a placebo over 10 weeks; results showed significant memory improvement in those taking donepezil.
- While donepezil was effective, it came with some side effects, notably diarrhea and nausea, and had a treatment-emergent adverse event rate of 46%, but overall, it demonstrated a favorable safety profile for treating memory impairments
Article Synopsis
- From 2009 to 2021, the Netherlands only offered bivalent HPV vaccination to girls, prompting an investigation into its effects on genital HPV prevalence among young adults.
- Data were collected through a study called PASSYON, which involved sexual health clinic clients aged 16-24, revealing significant declines in certain high-risk HPV types amongst vaccinated and unvaccinated females over time.
- The study highlighted successful herd protection effects of the vaccination for heterosexual males and unvaccinated females, while also indicating concerning trends of increasing HPV types related to vaccine phylogeny, suggesting potential type-replacement issues.
Background: Fecal microbiota transplantation (FMT) is an experimental treatment for ulcerative colitis (UC). We aimed to study microbial families associated with FMT treatment success.
Methods: We analyzed stools from 24 UC patients treated with four FMTs weekly after randomization for pretreatment during three weeks with budesonide (n = 12) or placebo (n = 12).
Introduction: Clostridioides difficile infection (CDI) is the most common cause of antibiotic-associated diarrhoea. Fidaxomicin and fecal microbiota transplantation (FMT) are effective, but expensive therapies to treat recurrent CDI (reCDI). Our objective was to develop a prediction model for reCDI based on the gut microbiota composition and clinical characteristics, to identify patients who could benefit from early treatment with fidaxomicin or FMT.
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- People with traumatic brain injury (TBI) often face emotional distress like anxiety and depression but might avoid mental health services due to various barriers.
- A study tested whether a self-monitoring intervention using a smartphone app could help reduce emotional distress in TBI patients by having them track their feelings weekly for six weeks.
- Results showed that the self-monitoring did not significantly lower emotional distress compared to the control group, highlighting the need for alternative interventions to support mental health in this population.