Publications by authors named "J J Nieto-Fontarigo"
Several studies have described the proteomic profile of different immune cell types, but only a few have also analysed the content of their delivered small extracellular vesicles (sEVs). The aim of the present study was to compare the protein signature of sEVs delivered from granulocytes (i.e.
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- The study investigates how asthma affects naïve/memory lymphocyte proportions through CD26 levels, aiming to link asthma phenotype/severity with variations in CD26 among various lymphocyte populations.* -
- Methods included flow cytometry analysis of blood samples from healthy and asthma patients to measure CD26 levels and characterize CD4CD26 T cell subsets, leading to the identification of four distinct inflammatory profiles.* -
- Results showed that neutrophilic asthma had lower CD4CD26 cells correlated with inflammation, while eosinophilic asthma had expanded CD26 subsets, particularly in atopic patients, indicating a role in chronic inflammation associated with allergic asthma.*
Background: Respiratory virus infections are main triggers of asthma exacerbations. Tezepelumab, an anti-TSLP mAb, reduces exacerbations in patients with asthma, but the effect of blocking TSLP on host epithelial resistance and tolerance to virus infection is not known.
Aim: To examine effects of blocking TSLP in patients with asthma on host resistance (IFNβ, IFNλ, and viral load) and on the airway epithelial inflammatory response to viral challenge.
Introduction: COPD causes high morbidity and mortality and high health costs. Thus, identifying and analyzing the distinctive and treatable traits seems useful to optimize the management of AEPOC patients. While various biomarkers have been researched, no solid data for systematic use have been made available.
View Article and Find Full Text PDFBackground: Airway hyperresponsiveness is a hallmark of asthma across asthma phenotypes. Airway hyperresponsiveness to mannitol specifically relates to mast cell infiltration of the airways, suggesting inhaled corticosteroids to be effective in reducing the response to mannitol, despite low levels of type 2 inflammation.
Objective: We sought to investigate the relationship between airway hyperresponsiveness and infiltrating mast cells, and the response to inhaled corticosteroid treatment.