Publications by authors named "J J Mansilla"
Article Synopsis
- Understanding how platelets influence oligodendrocyte progenitor cell (OPC) function is crucial for developing treatments for multiple sclerosis (MS).
- Research shows that platelets aggregate near OPCs in demyelinated areas, and reducing platelets leads to impaired OPC differentiation and remyelination.
- The study indicates that platelets have a dual role in remyelination, enhancing OPC differentiation initially but suppressing it with prolonged exposure, providing insights into remyelination challenges in MS.
Discoidin domain receptor 1 (DDR1) is a tyrosine kinase receptor expressed in epithelial cells from different tissues in which collagen binding activates pleiotropic functions. In the brain, DDR1 is mainly expressed in oligodendrocytes (OLs), the function of which is unclear. Whether collagen can activate DDR1 in OLs has not been studied.
View Article and Find Full Text PDFDuring the COVID-19 pandemic, the Pan American Health Organization (PAHO) promoted several activities to strengthen the countries' emergency response. Vaccines represented a breakthrough in the pandemic evolution, even though they have not been equitably distributed. As most vaccines have received emergency authorizations for their timely delivery, vaccine safety surveillance has been highlighted for detecting early signals of potential adverse events following immunization (AEFI, also known as ESAVI).
View Article and Find Full Text PDFProgressive nodular histiocytosis (PNH) is a rare type of non-Langerhans cell histiocytosis of the xanthogranuloma group. Less than 20 cases have been reported. We report here a novel case of PNH with dermoscopic description and post-surgical outcome.
View Article and Find Full Text PDFUse of Neurodynamic or Orthopedic Tension Tests for the Diagnosis of Lumbar and Lumbosacral Radiculopathies: Study of the Diagnostic Validity.
Int J Environ Res Public Health
September 2020
Background: Lumbar radiculopathy is a nerve root disorder whose correct diagnosis is essential. The objective of the present study was to analyze the reliability diagnostic validity of eight neurodynamic and/or orthopedic tension tests using magnetic resonance imaging as the Gold Standard.
Methods: An epidemiological study of randomized consecutive cases which was observational, descriptive, transversal, double blinded and was conducted following the Standards for Reporting Diagnostic accuracy studies (STARD) declaration.