Publications by authors named "J J Lepore"
Purpose: The American Dental Association advocates for dentists' education on therapeutic and legal issues related to medical cannabis. It is important to understand current knowledge of cannabis and cannabinoids and to have a practical knowledge assessment instrument. This exploratory study is the first of its kind to assess dental students' knowledge of cannabis and aims to determine if there is a need for more instruction regarding cannabis in a dental school's curriculum.
View Article and Find Full Text PDFGPR109A (HM74A), a G-protein-coupled receptor, is hypothesized to mediate lipid and lipoprotein changes and dermal flushing associated with niacin administration. GSK256073 (8-chloro-3-pentyl-1H-purine-2,6[3H,7H]-dione) is a selective GPR109A agonist shown to suppress fatty acid levels and produce mild flushing in short-term clinical studies. This study evaluated the effects of GSK256073 on lipids in subjects with low high-density lipoprotein cholesterol (HDLc).
View Article and Find Full Text PDFArticle Synopsis
- - This study examined the effects of daprodustat, a new oral medication for anemia in chronic kidney disease, focusing on its impact on hemoglobin levels and safety compared to traditional treatments like erythropoietin (rhEPO).
- - Participants (216) on hemodialysis were switched from rhEPO to daprodustat at varying doses and their hemoglobin levels were monitored over 24 weeks, with initial results showing significant hemoglobin increases in the daprodustat group during the first 4 weeks.
- - While both treatment groups showed similar hemoglobin levels after 24 weeks, daprodustat's safety profile was consistent with patients on hemodialysis, suggesting it could be a viable