Publications by authors named "J J LAFFERTY"
Article Synopsis
- - The laccase enzyme from fungi, combined with the mediator 1-HBT, effectively converts a lignin model compound with common linkages over 24 hours.
- - The primary reaction occurs at the β-O-4 ether linkage, yielding a known β-5 dimer intermediate that further degrades quickly.
- - Mass spectrometry indicates that the β-5 dimer and other degradation products can repolymerize to form larger oligomers, with proposed mechanisms for these catalytic processes.
There is a paucity of data on the cardiovascular implications of monoclonal gammopathy of undetermined significance, especially among hospitalized patients. Our study aimed to investigate the association between MGUS and cardiovascular outcomes in a hospital setting using the National Inpatient Sample database. MGUS patients were sampled using ICD-10 codes.
View Article and Find Full Text PDFMuch of what we remember is not because of intentional selection, but simply a by-product of perceiving. This raises a foundational question about the architecture of the mind: how does perception interface with and influence memory? Here, inspired by a classic proposal relating perceptual processing to memory durability, the level-of-processing theory, we present a sparse coding model for compressing feature embeddings of images, and show that the reconstruction residuals from this model predict how well images are encoded into memory. In an open memorability dataset of scene images, we show that reconstruction error not only explains memory accuracy, but also response latencies during retrieval, subsuming, in the latter case, all of the variance explained by powerful vision-only models.
View Article and Find Full Text PDFA central challenge for cognitive science is to explain how abstract concepts are acquired from limited experience. This has often been framed in terms of a dichotomy between connectionist and symbolic cognitive models. Here, we highlight a recently emerging line of work that suggests a novel reconciliation of these approaches, by exploiting an inductive bias that we term the relational bottleneck.
View Article and Find Full Text PDFBackground: With the widespread use of permanent pacemakers (PPM), and increased mortality associated with pacemaker endocarditis, it is essential to evaluate comorbidities that could potentially increase the risk of infective endocarditis (IE). Heart failure (HF), a common comorbidity, has not been well studied as an independent risk factor for development of IE in individuals with PPM.
Methods: The US National Inpatient Sample database was used to sample individuals with PPM.