Publications by authors named "J J Koornstra"
Article Synopsis
- * A study analyzed 200 individuals with Lynch syndrome to assess the effectiveness of faecal VOCs, both alone and in combination with FIT, in identifying relevant colorectal neoplasia before and after colonoscopy.
- * Results indicated high sensitivity and negative predictive values for detecting colorectal cancer and advanced adenomas using VOC analysis, suggesting that faecal VOCs could guide optimal colonoscopy intervals and improve patient monitoring following polypectomy.
Article Synopsis
- Endoscopic retrograde cholangiopancreatography (ERCP) with fully covered self-expandable metal stent (FCSEMS) is the main method for biliary drainage in cases of suspected malignant biliary obstruction, but it carries a high risk of post-ERCP pancreatitis (PEP).
- A study aimed to compare the effects of performing an endoscopic sphincterotomy before FCSEMS placement versus not performing it at all on the incidence of PEP.
- The trial included 297 patients and found no significant difference in PEP rates between those who had the sphincterotomy and those who did not, leading to the conclusion that routine sphincterotomy is not necessary before FCSEMS placement
Article Synopsis
- Colonoscopy surveillance for individuals with Lynch syndrome is challenging, and colorectal cancers can still occur despite regular screenings.
- A study evaluated the efficacy of fecal immunochemical tests (FIT) to determine the best intervals for colonoscopy by measuring specific thresholds of hemoglobin in stool samples.
- Results indicated that using a lower FIT threshold (2.5 μg Hb/g) increased the detection rate of relevant neoplasia, with even better specificity seen at a threshold of 4.1 μg Hb/g, suggesting that FIT could potentially allow many Lynch syndrome patients to delay unnecessary colonoscopies while still effectively identifying those at risk for advanced neoplasia.
Carriers of any pathogenic variant in one of the MMR genes ( carriers) were traditionally thought to be at comparable risk of developing a range of different malignancies, foremost colorectal cancer (CRC) and endometrial cancer. However, it is now widely accepted that their cancer risk and cancer spectrum range notably depending on which MMR gene is affected. Moreover, there is increasing evidence that the MMR gene affected also influences the molecular pathogenesis of Lynch syndrome CRC.
View Article and Find Full Text PDFA significant percentage of colonoscopies remain incomplete because of failure to intubate the cecum. The motorized spiral enteroscope (MSE) technique, originally developed for deep small bowel enteroscopy, may be an effective alternative technique in cases of incomplete examination of abnormally long colons (dolichocolon). We prospectively evaluated the success rate of cecal intubation, safety and the therapeutic consequences of using MSE after incomplete conventional colonoscopy.
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