Review of acute chemical incidents as a first step in evaluating the usefulness of physiologically based pharmacokinetic models in such incidents.

CONTEXT. Acute chemical incidents can have substantial public health consequences in terms of morbidity and mortality. OBJECTIVE.

Indoor air exposure to volatile compounds emitted by paints: experiment and model.

To describe the evaporation of organic solvents from paints and the resulting indoor concentrations, a mathematical model and an indoor paint experiment are presented. The model describes painting in terms of an increasing area of paint during application and two compartments of paint once applied. Evaporation of organic solvents is driven by the vapor pressure of the organic solvent.

Bioavailability of inorganic arsenic from bog ore-containing soil in the dog.

In some parts of The Netherlands, bog ore-containing soils predominate, which have natural arsenic levels that exceed, by a factor of 10, existing standards for maximum allowable levels of inorganic arsenic in soil. These standards are based on the assumption that in humans the bioavailability of arsenic from ingested soil is equal to that from an aqueous solution. In view of the regulatory problem that the arsenic levels of these soils present, we questioned the validity of this assumption.

Methods for source characterization of organic air pollutants.

Organic compounds are becoming increasingly more of interest as air pollutants, indoor as well as outdoor. Sources emitting such compounds are numerous and of various origin. For toxicological and epidemiological examination and for deciding on remedial actions information is required on the occurrences of compounds as well as on the emitting sources.

Problems, related to the occurrence of organic pollutants in the indoor environment.

Evaluation of the occurrence of organic compounds in the indoor environment is needed on at least two levels: 1. Evaluation of the overall prevalence of organic compounds in the indoor air. 2.