Publications by authors named "J J Karwacki"
Article Synopsis
- Avelumab is an antibody that targets PD-L1 in cancer cells, focusing on its effects on two potential cancer targets, CD15 and IL-17RA, which are influenced by the STAT3 protein.
- The study aimed to see if treating renal cancer cells with avelumab affects CD15 and IL-17RA expression and how STAT3 mediates this regulation.
- Results showed that avelumab treatment reduced STAT3 levels, increased CD15 expression in certain cancer cells, and altered IL-17RA levels only in healthy cells, highlighting the complex role these proteins play in cancer therapy.
Article Synopsis
- Lymphovascular invasion (LVI) is a key feature in prostate cancer that correlates with an increased risk of biochemical recurrence and other negative clinical outcomes.
- A systematic review of 94 studies showed that LVI significantly raises the likelihood of adverse factors such as advanced tumor stage, higher Gleason scores, and metastasis.
- The results suggest that LVI could serve as an important prognostic marker for assessing cancer recurrence risks following radical prostatectomy, although the study had limitations due to data variability and reliance on nonrandomized data.
Article Synopsis
- This study evaluated lymph node metastases in muscle-invasive bladder cancer patients who underwent a specific type of surgery called super-extended pelvic lymph node dissection (sePLND) and sentinel lymph node dissection (SLND).
- Out of 54 patients analyzed, 41% had metastases in their lymph nodes, with the obturator fossa being the most common location for these metastases.
- The findings suggest that metastases often occur on the opposite side of the tumor, making unilateral lymph node dissection risky, and combining sePLND with SLND offers better cancer staging.
The aim of this paper is to demonstrate the difference in usefulness of the coronary artery calcium score (CACS) and the full assessment of the severity of coronary artery disease in coronary computed tomography angiography (CCTA) studies. The difference between the population risk of coronary artery disease (CAD) assessed by the CACS and the severity of CAD was demonstrated in images from two CCTA studies. The first image is from a patient with a CACS of 0 and significant coronary artery stenosis.
View Article and Find Full Text PDFColorectal cancer (CRC) represents a substantial burden on global healthcare, contributing to significant morbidity and mortality worldwide. Despite advances in screening methodologies, its incidence remains high, necessitating continued efforts in early detection and treatment. Neoplastic invasion and metastasis are primary determinants of CRC lethality, emphasizing the urgency of understanding underlying mechanisms to develop effective therapeutic strategies.
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