Conventional Coagulation Tests are a better predictor of mortality than Viscoelastic Haemostatic Assays in trauma patients with shock: a prospective observational study.

Purpose: Conventional Coagulation Tests (CCTs) and Viscoelastic Haemostatic Assays (VHAs) are currently used in guiding trauma resuscitation. However, the role of these tests in predicting mortality is less known. This study aims to analyze both CCTs and VHAs in predicting mortality.

Hemocompatibility-Related Adverse Events Associated With or Without Low Molecular Weight Heparin Bridging in Outpatients With a HeartMate 3 Left Ventricular Assist Device.

Background: Prior studies of anticoagulation bridging during periods of low International Normalized Ratio (INR) in outpatients with a durable, continuous flow left ventricular assist device (CF-LVAD) have shown a variable impact on thrombotic and bleeding events. These studies include predominantly older devices such as the HeartMate 2 (HM2) and HeartWare HVAD, which are known to experience more overall thrombotic events than the HeartMate 3 (HM3) device. The majority of these patients also received concomitant aspirin.

Beyond platelet activation: dysregulated lipid metabolism in defining risk and pathophysiology of VITT.

Background: VITT has emerged as a rare but serious adverse event linked primarily to adenoviral vector COVID-19 vaccinations, such as ChAdOx1-S (Oxford/AstraZeneca) vaccination. The syndrome is characterized by thrombosis with thrombocytopenia, elevated D-dimer, and pathologic platelet factor 4 antibodies within 42 days of vaccination.

Objectives: Despite dysregulated lipid metabolism underpinning many thrombotic conditions, the role of lipid alterations in VITT remains unexplored.

Sex-Based Differences in Representation of Top Youth Athletes.

Objectives: Among overall top performances of youth track and swimming athletes, we aimed to determine: 1) the proportional number of male compared to female athletes represented and 2) at what age females are no longer represented.

Methods: Finishing times and sex of the top 10 and top 100 performances of youth runners and swimmers between 5-18 years were abstracted from online US-based databases for four running (100 m-800 m) and six freestyle swimming events (50 m-1500 m).

Results: Males represented a greater proportion of the top 10 performances starting at 7 years in running (P = 0.

Carbon source, cell density, and the microbial community control inhibition of surface colonization by environmental nitrate.

The intestinal diarrheal pathogen colonizes the host terminal ileum, a microaerophilic, glucose-poor, nitrate-rich environment. In this environment, respires nitrate and increases transport and utilization of alternative carbon sources via the cAMP receptor protein (CRP), a transcription factor that is active during glucose scarcity. Here, we show that nitrate respiration in aerated cultures is under control of CRP and, therefore, glucose availability.