Publications by authors named "J J Homer"
The impact of click chemistry was recently recognized with the 2022 Nobel Prize in Chemistry. The breadth of areas where click chemistry has accelerated discovery is prodigal. In one of the most written about subjects in chemistry over recent years, this short perspective zones in on a small fragment of what we, the authors, consider are some of the most critical developments in synthetic chemistry, which have expanded access to the click chemistry toolbox.
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- Phosphorus Fluoride Exchange (PFEx) is an advanced catalytic method that mimics natural processes to effectively bond phosphorus-fluoride compounds with various organic molecules like alcohols and amines, creating new and stable products.
- The reaction speed is improved through the use of Lewis amine base catalysts, particularly TBD, allowing for efficient exchange even with complex substrates containing multiple P-F bonds.
- PFEx enables the incorporation of new features into molecules with minimal steps and allows for late-stage modifications in drug development, showcasing its practical applications in creating diverse pharmaceutical compounds.