Docking and structure activity relationship studies of potent and selective thiazolidinethione GSK-3 inhibitors.

Glycogen synthase kinase-3 (GSK-3) plays a key role in several biochemical pathways and is an attractive target for pharmacological intervention. We prepared a series of analogs of a highly selective thiazolidinethione inhibitor of GSK-3. The structure-activity relationship indicated a precise structural requirement for potent inhibition.

COVID-19 vaccine uptake and associated risk factors among first antenatal care attendees in Zambia, 2021-2022: A repeated cross-sectional study.

Pregnant women are considered a high-risk group for COVID-19, and a priority for vaccination. Routine antenatal care (ANC) provides an opportunity to track trends and factors associated with vaccine uptake. We sought to evaluate COVID-19 vaccine uptake among pregnant women attending ANC and assess the factors associated with vaccine in Zambia.

Conservation: Meeting biodiversity targets through rewilding.

Rewilding is gaining popularity as a restoration approach that promotes passive ecological succession or the active reintroduction of keystone species. A new study identifies the best areas for rewilding in Europe to meet the ambitious 2030 biodiversity protection targets.