Publications by authors named "J J Greenlee"
Introduction: Efficacy of deep brain stimulation (DBS) is established for several movement and psychiatric disorders. However, the mechanism of action and local tissue changes are incompletely described. We describe neurohistopathological findings of 9 patients who underwent DBS for parkinsonism and performed a systematic literature review on postmortem pathologic reports post-DBS.
View Article and Find Full Text PDFUsing a prion amplification assay, we identified prions in tissues from wild pigs (Sus scrofa) living in areas of the United States with variable chronic wasting disease (CWD) epidemiology. Our findings indicate that scavenging swine could play a role in disseminating CWD and could therefore influence its epidemiology, geographic distribution, and interspecies spread.
View Article and Find Full Text PDFArticle Synopsis
- Chronic wasting disease (CWD) is a prion disease that impacts both wild and farmed elk, where infectious proteins cause normal proteins to misfold.
- A study used mass spectrometry to analyze prion proteins from elk inoculated with CWD, focusing on various peptides to measure prion quantity and composition.
- Results indicated differing amounts of prion proteins in the elk's brain tissue and highlighted the presence of methionine oxidation, demonstrating how mass spectrometry can help identify prion strains on a molecular level.
Matched oligoclonal bands: Diagnostic utility and clinical characteristics.
Ann Clin Transl Neurol
November 2024
Objective: To describe patient clinical characteristics associated with matched oligoclonal bands (OCB).
Methods: A retrospective review at the University of Utah examined patients with matched OCB from 2015 to 2020. Clinical data, diagnosis, and outcomes were collected.
Article Synopsis
- - The study explores the connection between parent mental health (specifically fathers) and the emotional well-being of their autistic children, revealing that both issues are closely linked.
- - Findings indicate that fathers' mental health, particularly their depression and critical comments, significantly affect both their children's mental health and the quality of their interactions, such as positive remarks.
- - The research suggests that improving the quality of parent-child relationships can help mitigate mental health issues for both fathers and their autistic children, although similar effects were not observed for mothers.