Publications by authors named "J J Glenn"
This work describes the design and implementation of optics for EXCLAIM, the EXperiment for Cryogenic Large-Aperture Intensity Mapping. EXCLAIM is a balloon-borne telescope that will measure integrated line emission from carbon monoxide at redshifts z < 1 and ionized carbon ([CII]) at redshifts z = 2.5 - 3.
View Article and Find Full Text PDFPortable and efficient cognitive screening measures are needed to address the growing need for effective early detection of Alzheimer's disease. The Neurotrack Cognitive Battery (NCB) offers an appealing, web-based application that may be sensitive to early cognitive changes associated with Alzheimer's disease. The NCB contains measures that were conceptually derived from animal lesion studies.
View Article and Find Full Text PDFPatient perceptions of opioid use disorder, drug and alcohol dependence.
J Opioid Manag
November 2024
Background: As the opioid epidemic continues, it behooves healthcare systems and practitioners to examine factors affecting access to care and treatment, as well as understand patient perceptions of opioid use disorder (OUD).
Methods: This was a cross-sectional sample of 124 patients with an OUD diagnosis identified using International Classification of Disease codes in electronic health records. Patients responded to a qualitative survey regarding self-perceptions and history of OUD, alcohol, and substance use.
Article Synopsis
- Tuberculosis is a major cause of death from infectious diseases, with the infection first occurring in the alveoli, where it interacts with alveolar lining fluid (ALF).
- Research indicates that as people age, ALF becomes more oxidized and inflammatory, which helps the bacteria (likely Mycobacterium tuberculosis) reproduce more effectively in human macrophages and type II alveolar epithelial cells (ATs).
- The study reveals that exposure to ALF from elderly humans (E-ALF) enhances the bacteria's ability to adapt and replicate by upregulating specific genes, suggesting that changes in lung mucosa with age significantly impact how tuberculosis develops and survives within human cells.
Article Synopsis
- - The study aimed to examine the occurrence of drug resistance mutations related to integrase strand transfer inhibitors (INSTI-DRMs) in children and adolescents with perinatally acquired HIV who were referred to a perinatal virtual clinic.
- - Among 114 cases reviewed from October 2018 to January 2024, 90% had available resistance sequences, with significant findings showing that many had prior ART exposure and a notable percentage of those developed INSTI-DRMs, primarily from low/middle-income countries.
- - The research recommended treatment adjustments, emphasizing the need for enhanced access to effective therapies and the importance of addressing drug resistance in this patient population, particularly those with extensive treatment histories.