Publications by authors named "J J Gehrig"
Article Synopsis
- Pharmaceutical drugs, especially corticosteroids, can adversely affect organ development in fetuses and very premature infants, with potential long-term consequences for kidney health.
- In a study using transgenic zebrafish, researchers found that various corticosteroids led to significant changes in kidney morphology and function, including hypertrophy of kidney structures and increased filtration rates.
- These findings highlight the need for careful consideration of corticosteroid use during pregnancy and in preterm infants, as they may pose risks to kidney development and overall health.
Standardizing image datasets is essential for facilitating overall visual comparisons and enhancing compatibility with image-processing workflows. One way to achieve homogeneity for images containing a single object is to align the object to a common orientation. Here, we propose the Virtual Orientation Tools (VOTj): a set of Fiji plugins to center and align an object of interest in images to a vertical or horizontal orientation.
View Article and Find Full Text PDFBackground: To compare fatigue, comfort, and muscle work associated with the use of two periodontal curettes during scaling: one with a novel adaptive design, the other with a conventional non-adaptive design.
Methods: Twelve hygienists scaled a typodont using two Universal Barnhart 5/6 curettes: (1) a prototype featuring an adaptive silicone-covered handle (Curette A), and (2) a stainless-steel curette (Curette B). Surface Electromyography (sEMG) traced muscle work.
Background: FSGS affects the complex three-dimensional morphology of podocytes, resulting in loss of filtration barrier function and the development of sclerotic lesions. Therapies to treat FSGS are limited, and podocyte-specific drugs are unavailable. To address the need for treatments to delay or stop FSGS progression, researchers are exploring the repurposing of drugs that have been approved by the US Food and Drug Administration (FDA) for other purposes.
View Article and Find Full Text PDFChronic kidney disease (CKD) is a major public health burden affecting more than 500 million people worldwide. Podocytopathies are the main cause for the majority of CKD cases due to pathogenic morphological as well as molecular biological alterations of postmitotic podocytes. Podocyte de-differentiation is associated with foot process effacement subsequently leading to proteinuria.
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