Publications by authors named "J J Geerling"
Land-based mazes that require spatial cues to identify the location of a hiding-place are a low-stress method to evaluate learning rate and memory retention in mice. One version, the Barnes maze, allows quantification of naturalistic exploratory behaviors not evident in water-based tasks. As the task relies on innate behaviors, it does not require overtraining, making it more feasible to examine early learning and non-memory executive functions that are characteristic of some non-amnestic dementias.
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- The nucleus of the solitary tract (NTS) processes vital visceral information and plays a key role in managing appetite, digestion, and respiratory functions.
- Researchers used histologic and transcriptomic techniques to analyze the various types of neurons in the NTS, identifying unique molecular characteristics among them.
- Most glutamatergic neurons in the NTS co-express the transcription factors Lmx1b and Phox2b, but certain neurons, like those producing GLP-1, differ in composition, indicating a complex organization within this important brain area.
Article Synopsis
- * Researchers have created a new mouse model that mimics chronic hydrocephalus with normal pressure, displaying similar symptoms to human NPH, including unsteady gait and subtle learning difficulties.
- * This model allows scientists to investigate the underlying neural mechanisms of NPH symptoms using advanced genetic techniques, potentially leading to new treatments.
Rationale And Objectives: Suspicious lesions detected in multiparametric breast MRI can be further analyzed with second-look ultrasound (SLUS) and/or mammography. This study aims to assess the value of second-look imaging in selecting the appropriate biopsy method for different lesion characteristics.
Materials And Methods: Between January 2021 and December 2023, 212 women underwent contrast-enhanced multiparametric breast MRI at 3 Tesla.
Article Synopsis
- Excessive production of aldosterone is linked to serious health risks, including heart disease, stroke, dementia, and increased mortality, primarily by promoting sodium retention and consumption.
- Researchers identified specific neurons in the human brain that are sensitive to aldosterone and express a genetic regulator called HSD2, which play a crucial role in salt intake.
- Experimental studies in mice confirmed that these HSD2 neurons are essential for aldosterone-induced salt consumption, suggesting they could be a potential target for treatments aimed at controlling dietary sodium intake.