Mechanism of female CHH caused by compound heterozygous mutations in the LHB gene.

Background: Luteinizing hormone (LH) plays a crucial role in the postnatal development and maturation of gonads. Inactivating mutations of the luteinizing hormone beta subunit (LHB)gene are extremely rare and can result in congenital hypogonadotropic hypogonadism (CHH).

Methods: We conducted DNA sequencing on an 18-year-old female patient with undetectable LH and clinical symptoms of CHH.

Prognostic and therapeutic implications of measurable residual disease levels during remission induction of childhood ALL.

We evaluated the prognostic and therapeutic significance of measurable residual disease (MRD) during remission induction in pediatric acute lymphoblastic leukemia (ALL) patients. In the CCCG-ALL-2015 protocol, 7640 patients were categorized into low-, intermediate-, or high-risk groups based on clinical and genetic features. Final risk classification was determined by MRD assessed via flow cytometry on Days 19 and 46 of remission induction, with additional intensified chemotherapy for Day 19 MRD ≥1%.

Public Health.

Background: Emerging evidence suggests that air pollution exposure might diminish the cognitive health of older adults. Although many studies have reported that air pollution is associated with increased dementia risk, associations with the process of cognitive decline have been more heterogeneous.

Method: We used biennial data between 2000 to 2016 from respondents>65 years in the Health and Retirement Study (HRS), a national, population-based cohort in the United States, to study associations of air pollution with cognitive decline.

Biomarkers.

Background: Dementia is prevalent over the world with unclear mechanism. Gene is supposed to play a vital role in the pathogenesis of dementia. However, the genetic basis of the majority of dementia patients is unknown.

Biomarkers.

Background: To assess the diagnostic efficacy of plasma biomarkers in distinguishing Alzheimer's pathologic changes from other forms of dementia, our study focused on examining plasma biomarkers in accordance with the AT(N) system.

Method: A total of 156 participants were recruited from the PUMCH dementia cohort. This comprised 55 non-AD (A-) and 101 Alzheimer's pathologic changes (A+) individuals.