Sexual Boredom Inventory (SBI): Development and Initial Validation.

This study presents the development and validation of the Sexual Boredom Inventory (SBI), a 6-item measure assessing sexual boredom as a temporary, context-dependent state. Initial items were drafted from data obtained through qualitative analysis, and the SBI was tested using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) with a sample of adults reporting on their sexual experiences in the past month. A single-factor model was found to be the best fit, with four items dropped during refinement.

Childhood Adversity and Telomere Length.

Exposure to adversity during childhood and adolescence is associated with numerous health conditions in adulthood; telomere shortening may be a mechanism through which adversity contributes to poor outcomes. We studied three areas of adversity (parent relational instability, child household instability, and financial instability) occurring during three epochs across childhood and adolescence and their associations with telomere length during adolescence. Data were obtained from the first wave of a longitudinal cohort study of youth aged 11-17 and their primary caregiver.

Modified human mesenchymal stromal/stem cells restore cortical excitability after focal ischemic stroke in rats.

Allogeneic modified bone marrow-derived human mesenchymal stromal/stem cells (hMSC-SB623 cells) are in clinical development for the treatment of chronic motor deficits after traumatic brain injury and cerebral ischemic stroke. However, their exact mechanisms of action remain unclear. Here, we investigated the effects of this cell therapy on cortical network excitability, brain tissue, and peripheral blood at a chronic stage after ischemic stroke in a rat model.

Neuroimaging markers of cognitive fatigue in individuals with post-acute sequelae of SARS-CoV-2 infection.

Persistent cognitive fatigue (CF) is the most reported symptom in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), but little is known about its underlying neural basis. This pilot study examined fMRI brain activation patterns during a fatiguing task in those with and without PASC. We hypothesized that individuals with PASC would show changes in CF-related brain activation within fatigue network.

Heterogeneity in Prescription Opioid Misuse Motives by Age in Adolescents and Young Adults in the United States.

Objective: Adolescent (12-17 years) and young adult (18-25 years) prescription opioid misuse (POM) is linked to poor health outcomes. We investigated how POM motives vary across these ages and the potential links between motives and other substance use, mental health, and sociodemographic characteristics to help guide screening and prevention.

Methods: Pooled 2015-2019 US National Survey on Drug Use and Health data were used, with 137,858 participants.