Estimating Mediation Effects in ABAB Reversal Designs.

Single-Case Experimental Designs (SCEDs), or N-of-1 trials, are commonly used to estimate intervention effects in many disciplines including in the treatment of youth mental health problems. SCEDs consist of repeated measurements of an outcome over time for a single case (e.g.

Integrated primary and community mental health care for young adults with serious mental illness: A program evaluation.

Aim: Young adults with serious mental illness (SMI) have poor physical health and high Emergency Department (ED) and hospital utilization. Integrating primary care into community mental health care may be an important form of early intervention.

Methods: Adjusted multivariable regressions assessed changes in self-reported annual primary care, ED and hospital utilization for 83 young adults with SMI enrolled in integrated care.

Level and timing of product substitution in a trial of e-cigarettes for smokers not interested in quitting.

Introduction: The e-cigarette market is large and diverse. Traditional smoking cessation trials involving a control group and a 6-month observation period are an inefficient methodology for testing the multiple treatment options e-cigarettes provide for harm reduction in cigarette smokers. We determined when product substitution occurred in the e-cigarette provision arm of an e-cigarette substitution trial for cigarette smokers who were not interested in quitting.

Fine-grained effect sizes.

To make transparent individuals' responses to intervention over time in the systematic review of single-case experimental designs, we developed a method of estimating and graphing fine-grained effect sizes. Fine-grained effect sizes are both case- and time-specific and thus provide more nuanced information than effect size estimates that average effects across time, across cases, or both. We demonstrate the method for estimating fine-grained effect sizes under three different baseline stability assumptions: outcome stability, level stability, and trend stability.

Tobacco, Alcohol, and Drug Use Among Young Adults with Serious Mental Illness.

To inform early intervention, this study describes correlates of substance use among young people with serious mental illness (SMI) enrolled in integrated care in community mental health settings. 227 adults ages 18-35 were assessed for clinical characteristics and substance use. Logistic regressions were used to describe relationships between substance use and participant characteristics.