Publications by authors named "J J Dudek"
Article Synopsis
- Impaired calcium (Ca) handling in heart cells is a key feature of heart failure (HF), leading to issues like weakened heart contractions and irregular heartbeats.
- The study used transgenic mice with a mutation affecting a calcium regulator (phospholamban) to understand how defects in calcium cycling contribute to HF, noting that these mice experience severe and fast-progressing heart failure.
- Early treatment aimed at correcting calcium cycling using Raf kinase inhibitor protein (RKIP) was found to delay heart cell damage and improve overall health of the mice, indicating that addressing Ca dynamics early on could be crucial for preventing further complications in heart failure.
Objectives: Propose a methodology to identify COVID-19 associated deaths using healthcare billing records and evaluate its effectiveness by comparing the results with excess mortality data from 2020 to 2022 and confirmed COVID-19 deaths.
Methods: A retrospective quantitative analysis was conducted by merging healthcare billing records with cause of death data. The term "COVID-19 associated death" was defined as any death occurring within a defined timeframe following a confirmed contact with COVID-19.
The Effect of Oil Additives on the Properties of Fly Ash-Based Foamed Geopolymers.
Materials (Basel)
November 2024
Geopolymers are a modern class of construction materials that show significant potential for sustainable development, especially through the use of industrial wastes such as fly ash. This study investigated the effect of different oil additives on the properties of fly ash-based geopolymers, with particular emphasis on the use of both new and used oils. Test samples were prepared using class F fly ash and a 10-molar solution of sodium hydroxide and an aqueous solution of sodium silicate.
View Article and Find Full Text PDFAims: Obesity increases the risk of heart failure with preserved (HFpEF), but not reduced ejection fraction (HFrEF). The glucagon-like peptide-1 receptor agonist (GLP-1-RA) semaglutide improves outcome of patients with obesity with or without HFpEF, while GLP-1-RAs were associated with adverse outcome in patients with HFrEF. Here, we investigate the effect of in vivo treatment with semaglutide on excitation-contraction coupling in a rat model of obesity.
View Article and Find Full Text PDFArticle Synopsis
- Bacterial biofilms act as protective barriers, making it difficult for antibiotics to work effectively, but introducing oxygen can improve their effectiveness.
- This study investigates the use of oxygen-producing calcium peroxide nanoparticles (CaO NP) combined with tobramycin sulfate (Tob) on Pseudomonas aeruginosa biofilms, showing that the combination significantly enhances biofilm eradication compared to using Tob alone.
- In natural biofilms from human mouths, CaO NP increased the percentage of dead bacteria, and when combined with Tob, the dead bacteria percentage rose even further, demonstrating its potential benefits in real-life applications.