Publications by authors named "J J Cruz-Hernandez"

Background: In recent years, cancer survival rates have increased exponentially. However, this rise in survival comes with a significant drawback. As the number of treatment lines has grown, so too have the side effects, which can severely impact patients' functionality and quality of life.

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Background: In recent years, there has been a significant increase in the survival rates of cancer patients. However, this has also led to an increase in side effects, such as dyspnoea, which can negatively impact of patients. We propose a programme for re-educating effort.

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Article Synopsis
  • Luminal A breast cancer has a good outlook, but around 10% of patients may have tumors come back after 10 years, especially within the first 5 years after diagnosis.
  • A study was done to see how a specific protein called NCAPH affects the growth of luminal A breast cancer, looking for gene patterns that could indicate a higher risk of bad outcomes.
  • The findings showed that high levels of NCAPH are linked to more aggressive tumors and poorer responses to chemotherapy, leading to a new gene score (GSLA10) that can help predict which patients might have worse outcomes.
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Traditional microbiological methodology is valuable and essential for microbiota composition description and microbe role assignations at different anatomical sites, including cervical and vaginal tissues; that, combined with molecular biology strategies and modern identification approaches, could give a better perspective of the microbiome under different circumstances. This pilot work aimed to describe the differences in microbiota composition in non-cancer women and women with cervical cancer through a culturomics approach combining culture techniques with Vitek mass spectrometry and 16S rDNA sequencing. To determine the possible differences, diverse statistical, diversity, and multivariate analyses were applied; the results indicated a different microbiota composition between non-cancer women and cervical cancer patients.

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Background: Non-small cell lung cancer (NSCLC) has undergone a major change in the last decade in terms of survival and prognosis due to the introduction of new drugs in the last 10 years. One of the drugs with the most promising preliminary results in NSCLC are PARP inhibitors (iPARPs), whose clinical trials have very heterogeneous results. The use of iPARPs in NSCLC may lead to increased survival in several selected patients, and their use may become a standard in the coming years.

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