Publications by authors named "J J Chomel"
Int J Mol Sci
October 2023
Article Synopsis
- - Acute myeloid leukemia (AML) with a specific fusion gene is now recognized as a unique subtype, making it crucial to differentiate it from myeloid blast crisis chronic myeloid leukemia (BC-CML), particularly those without a chronic phase.
- - The study analyzed a diverse cohort of CML and AML patients, revealing that the fusion functioned as an essential genetic marker in characterizing AML, while also unearthing AML-specific mutations and distinct gene expression patterns.
- - Findings indicate that specific gene expressions, particularly of mRNAs like ID4, can help differentiate AML with the fusion from BC-CML, suggesting that further research is needed to validate these distinctions and deepen the understanding of this AML subtype.
Article Synopsis
- F-FDG PET/CT is important for diagnosing and monitoring Hairy Cell Leukemia (HCL), especially in atypical cases with bone involvement.
- The study highlighted two patients with BRAF mutation who had significant bone lesions and limited bone marrow infiltration, demonstrating the utility of F-FDG PET/CT.
- The authors emphasize integrating F-FDG PET/CT into standard HCL management to improve patient outcomes and detect less common manifestations.
Article Synopsis
- Myeloproliferative neoplasms in the blastic phase (MPN-BP) have a poor prognosis, but a study on five patients showed promising results with a new treatment combining azacytidine, venetoclax, and ruxolitinib.*
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- The patients, aged between 72 and 84, had an overall response rate of 80%, with 40% achieving complete remission during a median follow-up of 10 months.*
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- There were no unexpected toxicities from the treatment, and the patients experienced an improved quality of life, with a median overall survival of 13.4 months.*
Article Synopsis
- - The study investigates the role of a specific oncofetal protein as a potential biomarker for chronic myeloid leukemia (CML), which is a cancer affecting blood-forming cells caused by genetic changes.
- - Researchers employed various techniques, including cell culture and ELISA, to demonstrate that this protein is overexpressed in CML patients and may be linked to the disease's progression and severity.
- - Findings indicate that the protein is upregulated in a kinase-dependent way and may significantly contribute to the mechanisms driving leukemogenesis in CML.
