Accuracy of a Laryngopharyngeal Endoscopic Esthesiometer (LPEER) for Evaluating Laryngopharyngeal Mechanosensitivity: A Validation Study in a Prospectively Recruited Cohort of Patients.

Recent studies have shown an association between alterations in laryngopharyngeal mechanosensitivity (LPMS) and dysphagia, obstructive sleep apnea, and chronic cough hypersensitivity syndrome. A previous reliability study of a new laryngopharyngeal endoscopic esthesiometer and rangefinder (LPEER) showed high intra- and inter-rater reliability; however, its accuracy has not been tested. We performed an accuracy study of the LPEER in a prospectively and consecutively recruited cohort of 118 patients at two tertiary care university hospitals.

[Abortive activity of mimosine and its prevention (author's transl)].

18 out of 19 female mice treated orally with different levels of mimosine in the drinking water were fertile. Subcutaneous injection of mimosine (400 mg/kg) to 23 pregnant mice, in a single dose on days 5, 10, 15 or 17, resulted in death and resorption or expulsion of dead embryos, except in one, early inoculated. L-Phenylalanine (600 mg/kg) injected subcutaneously on day 17 prevented abortion in 4 out of 5 mice subsequently injected with mimosine.