A-3665, a new short-acting opioid: a comparison with alfentanil.

A-3665 is a new short-acting synthetic opioid of the piperidine class. We conducted a double-blind, escalating dose comparison of A-3665 to alfentanil and placebo. Analgesic efficacy was assessed after the administration of A-3665 in increasing intravenous doses (0.

Apparent ionophoric effects of red blood cell deformation.

Normal human RBCs in vitro demonstrated increased utilization of ATP in when subjected to shear stress. Much of the increased ATP utilization appeared to be due to stimulation of membrane ion pumps. Thus, there was an apparent ionophoric effect of RBC deformation.