Publications by authors named "J J C Sidrim"
Geraniol inhibits both planktonic cells and biofilms of the Candida parapsilosis species complex: Highlight for the improved efficacy of amphotericin B, caspofungin and fluconazole plus Geraniol.
Med Mycol
November 2024
Article Synopsis
- The Candida parapsilosis species complex is a significant concern in healthcare settings due to rising antifungal resistance.
- Geraniol, a terpene from essential oils, has demonstrated potential antimicrobial effects against this yeast species in both planktonic and biofilm forms.
- In lab tests, geraniol showed an effective minimum inhibitory concentration (MIC) between 256-512 µg/ml and reduced biofilm activity, while also enhancing the effectiveness of certain antifungal medications like amphotericin B and fluconazole.
Antimicrobial and antibiofilm effect of promethazine on bacterial isolates from canine otitis externa: an in vitro study.
Microb Pathog
November 2024
Article Synopsis
- Otitis externa is a condition in dogs where the external ear canal becomes inflamed, usually due to bacterial infections, and this study focuses on testing promethazine's effectiveness against it.
- * The research evaluated how promethazine affects bacterial growth and biofilm formation over 120 hours, determining its minimum inhibitory concentrations (MIC) and minimum biofilm eradication concentration (MBEC).
- * Results showed that promethazine significantly reduced biofilm growth and could be a promising treatment for recurring bacterial otitis in dogs, highlighting the benefits of repurposing existing drugs to combat antimicrobial resistance.
Article Synopsis
- The article investigates the use of carbonyl cyanide m-chlorophenyl hydrazone (CCCP) as an efflux pump inhibitor to combat antimicrobial resistance and biofilm formation.
- It found that CCCP significantly reduces biofilm biomass and enhances the effectiveness of antibiotics against biofilms when used at certain concentrations (128 µM and 512 µM).
- CCCP also impacts the production of virulence factors, decreasing protease production and increasing siderophore release, indicating its potential as a therapeutic aid in managing infections related to biofilms.
Cryptococcal biofilms have been associated with persistent infections and antifungal resistance. Therefore, strategies, such as the association of natural compounds and antifungal drugs, have been applied for the prevention of biofilm growth. Moreover, the pathogenicity model has been used to investigate the capacity to inhibit the pathogenicity of .
View Article and Find Full Text PDFThis study evaluated the antibiofilm activity of promethazine, deferiprone, and Manuka honey against Staphylococcus aureus and Pseudomonas aeruginosa in vitro and ex vivo in a wound model on porcine skin. The minimum inhibitory concentrations (MICs) and the effects of the compounds on biofilms were evaluated. Then, counting colony-forming units (CFUs) and confocal microscopy were performed on biofilms cultivated on porcine skin for evaluation of the compounds.
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