Publications by authors named "J J Bonner"
Article Synopsis
- In 2022, the monkeypox virus outbreak prompted the need for immediate public health responses, leading to the exploration of plant-derived monoclonal antibodies (mAbs) as potential treatments due to their antiviral properties.
- The study specifically focuses on developing a plant-derived mAb that targets the extracellular enveloped virion (EV) of MPXV, which is crucial for the virus's spread and resistant to neutralization.
- The findings confirm that the plant-made mAb, named H2, effectively binds to the MPXV EV and neutralizes it, marking a significant advancement in therapeutic strategies against monkeypox and highlighting the potential of plant-based antibodies for treating emerging infectious diseases.
Hypoxia is a common feature in various pathophysiological contexts, including tumor microenvironment, and IFN-γ is instrumental for anti-tumor immunity. HIF1α has long been known as a primary regulator of cellular adaptive responses to hypoxia, but its role in IFN-γ induction in hypoxic T cells is unknown. Here, we show that the HIF1α-glycolysis axis controls IFN-γ induction in both human and mouse T cells, activated under hypoxia.
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- * A study identified a specific genetic variation at Chr6:31373718C>G that is associated with increased CRC risk, particularly in the younger population, with stronger odds for EOCRC compared to older adults.
- * Analysis showed that individuals carrying the minor G allele have reduced expression of the immune-related MICA gene and lower levels of Natural Killer (NK) cell infiltration in tumors, suggesting a link between this genetic variation and tumor immune response.
Background: Excessive car use hampers progress toward tackling global health challenges, including climate and sustainability issues, and is linked to lower physical activity. Local communities have been developing solutions through bike buses. This paper, one of the first on bike buses, explores how a bike bus is perceived by other road and place users.
View Article and Find Full Text PDFThe increasing use of multiwalled carbon nanotubes (MWCNTs) could increase the risk of allergic lung disease in occupational or consumer settings. We previously reported that MWCNTs exacerbated allergic lung disease in mice induced by extract from house dust mites (HDM), a common cause of asthma in humans. Because MWCNTs avidly bind biomolecules to form protein coronas that can modify immunotoxicity, we hypothesized that exacerbation of allergic lung disease in mice caused by coexposure to MWCNTs and HDM extract was due to the formation of an allergen corona.
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