Chemoselective Proteomics, Zinc Fingers, and a Zinc(II) Model for HS Mediated Persulfidation.

The gasotransmitter hydrogen sulfide (HS) is thought to be involved in the post-translational modification of cysteine residues to produce reactive persulfides. A persulfide-specific chemoselective proteomics approach with mammalian cells has identified a broad range of zinc finger (ZF) proteins as targets of persulfidation. Parallel studies with isolated ZFs show that persulfidation is mediated by Zn, O, and HS, with intermediates involving oxygen- and sulfur-based radicals detected by mass spectrometry and optical spectroscopies.

The Impact of a National Cyberattack Affecting Clinical Trials: The Cancer Trials Ireland Experience.

Purpose: Cyberattacks are increasing in health care and cause immediate disruption to patient care, have a lasting impact, and compromise scientific integrity of affected clinical trials. On the May 14, 2021, the Irish health service was the victim of a nationwide ransomware attack. Patient care was disrupted across 4,000 locations, including 18 cancer clinical trials units associated with Cancer Trials Ireland (CTI).

Magnetic fields of 30 to 100 kG in the cores of red giant stars.

A red giant star is an evolved low- or intermediate-mass star that has exhausted its central hydrogen content, leaving a helium core and a hydrogen-burning shell. Oscillations of stars can be observed as periodic dimmings and brightenings in the optical light curves. In red giant stars, non-radial acoustic waves couple to gravity waves and give rise to mixed modes, which behave as pressure modes in the envelope and gravity modes in the core.

Geometrical variations of two manganese(II) complexes with closely related quinoline-based tripodal ligands.

Structural analyses of the compounds di-μ-acetato-κ :'-bis-{[2-meth-oxy-,-bis-(quinolin-2-ylmeth-yl)ethanamine-κ ,','',]manganese(II)} bis-(tetra-phen-yl-borate) di-chloro-methane 1.45-solvate, [Mn(CO)(CHNO)](CHB)·1.45CHCl or [Mn(DQMEA)(μ-OAc)Mn(DQMEA)](BPh)·1.

Effects of HER Family-targeting Tyrosine Kinase Inhibitors on Antibody-dependent Cell-mediated Cytotoxicity in HER2-expressing Breast Cancer.

Purpose: Antibody-dependent cell-mediated cytotoxicity (ADCC) is one mechanism of action of the monoclonal antibody (mAb) therapies trastuzumab and pertuzumab. Tyrosine kinase inhibitors (TKIs), like lapatinib, may have added therapeutic value in combination with mAbs through enhanced ADCC activity. Using clinical data, we examined the impact of lapatinib on HER2/EGFR expression levels and natural killer (NK) cell gene signatures.