Publications by authors named "J J Baechle"
Article Synopsis
- The number of people getting gastric adenocarcinoma (GC) is going down, but there are still big differences between different racial and ethnic groups.
- Hispanic people are often diagnosed younger and have worse results compared to non-Hispanic people.
- A study found that Hispanic patients have a higher rate of a specific gene change (ERBB2/HER2 amplification) that can affect their treatment, so making sure everyone has access to the right tests and medicines could help improve these differences.
Microgravity is associated with immunological dysfunction, though the mechanisms are poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear cells (PBMCs) exposed to short term (25 hours) simulated microgravity, we characterize altered genes and pathways at basal and stimulated states with a Toll-like Receptor-7/8 agonist. We validate single-cell analysis by RNA sequencing and super-resolution microscopy, and against data from the Inspiration-4 (I4) mission, JAXA (Cell-Free Epigenome) mission, Twins study, and spleens from mice on the International Space Station.
View Article and Find Full Text PDFThe recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space and preparations for exploration-class (lasting longer than one year) missions. Such rapid advancement into space from many new companies, countries and space-related entities has enabled a 'second space age'. This era is also poised to leverage, for the first time, modern tools and methods of molecular biology and precision medicine, thus enabling precision aerospace medicine for the crews.
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- This study looked at patients with a type of cancer called pancreatic neuroendocrine tumors (PNETs) and how their living situations (urban vs. rural) affected their health outcomes.
- Out of 1176 patients, most lived in cities, while a smaller group lived in the countryside.
- The results showed that patients in rural areas had shorter survival times after surgery compared to those in urban areas, even when taking into account other factors like income and access to healthcare.
Background: Recently, the hallmarks of aging were updated to include dysbiosis, disabled macroautophagy, and chronic inflammation. In particular, the low-grade chronic inflammation during aging, without overt infection, is defined as "inflammaging," which is associated with increased morbidity and mortality in the aging population. Emerging evidence suggests a bidirectional and cyclical relationship between chronic inflammation and the development of age-related conditions, such as cardiovascular diseases, neurodegeneration, cancer, and frailty.
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