Publications by authors named "J J Attema"
Laughing is ubiquitous in human life, yet what causes it and how it sounds is highly variable. Considering this diversity, we sought to test whether there are fundamentally different kinds of laughter. Here, we sampled spontaneous laughs ( = 887) from a wide range of everyday situations (e.
View Article and Find Full Text PDFFibroblast growth factor 21 (FGF21) is a promising target for treatment of obesity-associated diseases including metabolic dysfunction-associated steatohepatitis (MASH) and atherosclerosis. We evaluated the effects of the bispecific anti-FGF21-β klotho (KLB) agonist antibody bFKB1 in a preclinical model of MASH and atherosclerosis. Low-density lipoprotein receptor knockout (Ldlr-/-).
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- A target discovery pipeline was created to identify drug targets for metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis by using a combination of molecular networks, text mining, and machine learning integrated with clinical data.
- Key genes influencing disease progression were pinpointed through knockout studies, leading to target efficacy analysis which confirmed the top-5 gene targets, including EP300, as significant contributors to liver fibrosis.
- Gene-silencing of EP300 notably reduced collagen levels in hepatic cells, demonstrating the pipeline's effectiveness in uncovering relevant drug targets and pathways for treating liver diseases.
Article Synopsis
- The prevalence of sarcopenia is on the rise, making it essential to find effective intervention tests, although existing methods can be difficult and costly.
- Researchers evaluated three mouse models that simulate factors contributing to sarcopenia: partial immobilization (sedentary lifestyle), caloric restriction (CR), and a combination of both.
- The findings suggested that the combined model best reflects human muscle aging by showing significant loss of muscle mass and function, highlighting the relevance of lifestyle factors like inactivity and poor nutrition in the development of sarcopenia.
Background: NAFLD progression, from steatosis to inflammation and fibrosis, results from an interplay of intra- and extrahepatic mechanisms. Disease drivers likely include signals from white adipose tissue (WAT) and gut. However, the temporal dynamics of disease development remain poorly understood.
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