Synaptic Targets and Cellular Sources of CB1 Cannabinoid Receptor and Vesicular Glutamate Transporter-3 Expressing Nerve Terminals in Relation to GABAergic Neurons in the Human Cerebral Cortex.

Cannabinoid receptor 1 (CB1) regulates synaptic transmission through presynaptic receptors in nerve terminals, and its physiological roles are of clinical relevance. The cellular sources and synaptic targets of CB1-expressing terminals in the human cerebral cortex are undefined. We demonstrate a variable laminar pattern of CB1-immunoreactive axons and electron microscopically show that CB1-positive GABAergic terminals make type-2 synapses innervating dendritic shafts (69%), dendritic spines (20%) and somata (11%) in neocortical layers 2-3.

Scallop fishing activity characterization in Southern New England: Offshore wind demands and fisheries-dependent methods.

Managers attempt to minimize spatial use conflicts in siting of offshore wind developments, but they must rely on available data to balance biological, commercial, and recreational needs. Marine spatial planning products are only as good as the data they are built upon and fishing data present major challenges due to their confidentiality and the difficulty in isolating true fishing activity. We present a methodology to increase the spatiotemporal resolution of fishing effort and exposure estimates for Southern New England scallop fishing activity using random decision forests to perform supervised classification on AIS data, with fallback to lower resolution datasets for vessels without AIS coverage.

General and anxiety-linked influences of acute serotonin reuptake inhibition on neural responses associated with attended visceral sensation.

Ordinary sensations from inside the body are important causes and consequences of our affective states and behaviour, yet the roles of neurotransmitters in interoceptive processing have been unclear. With a within-subjects design, this experiment tested the impacts of acute increases of endogenous extracellular serotonin on the neural processing of attended internal sensations and the links of these effects to anxiety using a selective serotonin reuptake inhibitor (SSRI) (20 mg CITALOPRAM) and a PLACEBO. Twenty-one healthy volunteers (fourteen female, mean age 23.

Feasibility of unconscious instrumental conditioning: A registered replication.

The extent to which high-level, complex functions can proceed unconsciously has been a topic of considerable debate. While unconscious processing has been demonstrated for a range of low-level processes, from feature integration to simple forms of conditioning and learning, theoretical contributions suggest that increasing complexity requires conscious access. Here, we focus our attention on instrumental conditioning, which has been previously shown to proceed without stimulus awareness.

The functional role of cardiac activity in perception and action.

SKORA, L.I., J.