Publications by authors named "J J A J van der Velden"
Cancer cachexia (CC), a syndrome of skeletal muscle and adipose tissue wasting, reduces responsiveness to therapies and increases mortality. There are no approved treatments for CC, which may relate to discordance between pre-clinical models and human CC. To address the need for clinically relevant models, we generated tamoxifen-inducible, epithelial cell specific ( ) mice.
View Article and Find Full Text PDFEmbryonic signaling pathways exert stage-specific effects during cardiac development, yet the precise signals for proliferation or maturation remain elusive. To uncover the cues for proliferation, we performed a combinatory cell-cycle screen for insulin and glycogen synthase kinase-3 (GSK3) inhibition in spontaneously beating human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Our analysis for proliferation, and subsequential downstream sarcomere development, gene expression analysis, and molecular interventions identified a temporal interplay between insulin/Akt/FOXO and CHIR99021/Wnt/GSK3/TCF signaling.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to investigate how removing one ovary for ovarian tissue cryopreservation (OTC) affects the remaining ovary's function in girls with Turner syndrome, monitoring them over several years to track pubertal development and hormone levels.
- - Conducted at a university hospital in the Netherlands, the research involved 28 girls aged 5-19, each with different karyotypes associated with Turner syndrome, and analyzed their hormone levels and pubertal milestones post-OTC.
- - Results showed a mixed response; while many participants experienced normal pubertal developments like thelarche and menarche, a notable decline in anti-Müllerian hormone (AMH) levels occurred shortly after OTC, leading to some girls requiring hormone replacement
Article Synopsis
- There is currently no minimally invasive option for treating unstable cervical metastases that provides immediate stability without significant complications, leading researchers to examine halo fixation and radiotherapy as alternatives.
- In a study of 20 patients treated over the past decade, halo fixation was used for an average of 83 days along with tailored radiotherapy to aid recovery of bone lesions.
- Results showed that patients experienced complete pain relief or significant reduction in pain, successful reossification of vertebrae, and mostly preserved neck motion, suggesting halo fixation combined with radiotherapy could be a safer option for certain patients compared to traditional surgery.