Publications by authors named "J Izopet"
Background: The persistence of latently infected cells prevents a cure of HIV. The intestinal mucosa contains numerous target cells, and high levels of HIV-1 DNA persist in this compartment under ART. While CD4+ T cells are the best characterized reservoir of HIV-1, the role of long-lived intestinal macrophages in HIV-1 persistence on ART remains controversial.
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- The study aimed to compare the antibody response to SARS-CoV-2 in patients with inflammatory rheumatic diseases and healthy individuals.
- Researchers screened unvaccinated patients with conditions like rheumatoid arthritis, spondyloarthritis, and psoriatic arthritis in France, and matched them with seropositive healthcare workers as controls.
- Results showed no significant difference in antibody levels between both groups, with a trend indicating that patients with severe COVID-19 symptoms had higher antibody titres; treatments like glucocorticoids seemed linked to lower antibody responses.
Accurate HIV-1 genome sequencing is necessary to identify drug resistance mutations (DRMs) in people with HIV-1 (PWH). Next-generation-sequencing (NGS) allows the detection of minor variants and is now available in many laboratories. Our study aimed to compare two NGS approaches, a "short read" sequencing protocol using DeepChek® Whole Genome HIV-1 Assay on Illumina, and a "long read" sequencing protocol of HIV-1 pol and env single-molecule real-time sequencing (SMRT) on Pacific Biosciences (PacBio).
View Article and Find Full Text PDFBackground And Aims: Several symptomatic cases of HEV infections were reported to the New Caledonia Island Public Health Service between August and December 2023. This prompted epidemiological and virological investigations to identify the source of infection.
Approach And Results: HEV RNA was assessed in symptomatic patients, various food items, and pig farms on the Island.
Background And Aims: Chronic hepatitis D infection is the most severe form of viral hepatitis and can rapidly progress to cirrhosis or hepatocellular carcinoma. Despite recommendations for systematic screening of hepatitis B surface antigen (HBsAg)-positive individuals, data from real-world studies have reported a low frequency of hepatitis D (or delta) virus (HDV) screening. Our cross-sectional analysis evaluated the diagnostic cascade for hepatitis D infection in tertiary centres and described the characteristics of HDV-positive patients.
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