Publications by authors named "J Iserte"
Mosquitoes are the primary vectors of arthropod-borne pathogens. Aedes aegypti is one of the most widespread mosquito species worldwide, responsible for transmitting diseases such as Dengue, Zika, and Chikungunya, among other medically significant viruses. Characterizing the array of viruses circulating in mosquitoes, particularly in Aedes aegypti, is a crucial tool for detecting and developing novel strategies to prevent arbovirus outbreaks.
View Article and Find Full Text PDFProtein cis-regulatory elements (CREs) are regions that modulate the activity of a protein through intramolecular interactions. Kinases, pivotal enzymes in numerous biological processes, often undergo regulatory control via inhibitory interactions in cis. This study delves into the mechanisms of cis regulation in kinases mediated by CREs, employing a combined structural and sequence analysis.
View Article and Find Full Text PDFThe MobiDB database (URL: https://mobidb.org/) is a knowledge base of intrinsically disordered proteins. MobiDB aggregates disorder annotations derived from the literature and from experimental evidence along with predictions for all known protein sequences.
View Article and Find Full Text PDFMotivation: Proteins involved in liquid-liquid phase separation (LLPS) and membraneless organelles (MLOs) are recognized to be decisive for many biological processes and also responsible for several diseases. The recent explosion of research in the area still lacks tools for the analysis and data integration among different repositories. Currently, there is not a comprehensive and dedicated database that collects all disease-related variations in combination with the protein location, biological role in the MLO, and all the metadata available for each protein and disease.
View Article and Find Full Text PDFArticle Synopsis
- Crohn Disease (CD) is an inflammatory bowel condition linked to high levels of inflammatory cytokines, and treatments often include TNF-α inhibitors like adalimumab and certolizumab.
- This case report details a 65-year-old man with CD who developed erectile dysfunction (ED) correlated with two consecutive TNF-α treatments, which resolved upon switching to a different biologic drug, ustekinumab.
- The findings suggest that while similar biologics may have comparable effects, they can lead to different side effects, emphasizing the importance of medication choice in treating conditions like CD.