Publications by authors named "J Inatomi"

Human epidermal growth factor receptors (HER/ERBB) form dimers that promote cell proliferation, migration, and differentiation, but overexpression of HER proteins results in cancer. Consequently, inhibitors of HER dimerization may function as effective antitumor drugs. An alternatively spliced variant of HER2, called herstatin, is an autoinhibitor of HER proteins, and the intron 8-encoded 79-residue domain of herstatin, called Int8, binds HER family receptors even in isolation.

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Article Synopsis
  • - A case study highlighted a 5-year-old girl who developed a renal abscess due to ESBL-producing E. coli, resulting in serious complications like bacteremia and kidney scarring.
  • - Initially treated for a urinary tract infection with standard antibiotics, her condition worsened, leading to the discovery of the abscess through a CT scan, prompting a switch to meropenem for treatment.
  • - The report emphasizes the need for clinicians to recognize the risks of renal abscesses from resistant bacteria in previously healthy children and stresses the importance of prompt diagnosis and management to prevent severe outcomes.
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Background: The precise mechanism of hyponatremia in Kawasaki disease (KD) remains elusive because assessment of volume status based on serial changes in body weight is lacking in previous reports.

Methods: Seventeen patients who were diagnosed with KD and hyponatremia (serum sodium levels <135 mmol/L) were analyzed. Volume status was assessed based on serial changes in body weight.

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Background: Although early treatment of Kawasaki disease (KD) with i.v. immunoglobulin (IVIG) is expected to prevent coronary artery abnormalities, the effectiveness of IVIG by day 4 of illness remains to be determined.

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Background: Resistance to intravenous immunoglobulin (IVIG) therapy is a risk factor for coronary lesions in patients with Kawasaki disease (KD). Risk-adjusted initial therapy may improve coronary outcome in KD, but identification of high risk patients remains a challenge. This study aimed to develop a new risk assessment tool for IVIG resistance using advanced statistical techniques.

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