Publications by authors named "J Imamura"
This case report discusses the case of a 74-year-old man who was diagnosed with hereditary hemorrhagic telangiectasia (HHT). The patient initially presented with right upper quadrant abdominal pain and was later diagnosed with cholangitis. Subsequently, heart failure was identified due to hepatic arteriovenous malformations.
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- * It involved 179 female patients and used a decision tree model to analyze data including dementia score, muscle mass, body mass index, grip strength, and the number of fractures or injuries at admission.
- * Results indicated that lower skeletal muscle mass index, older age, and weaker grip strength at admission are key predictors of whether a patient will need help with stair climbing upon discharge.
Introduction: This study aimed to evaluate the efficacy and safety of atezolizumab combined with bevacizumab (Atez/Bev) compared to lenvatinib (LEN) as first-line systemic therapy for patients with Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC) exceeding the up-to-seven criteria threshold, who are typically unsuitable for transarterial chemoembolization (TACE).
Methods: A retrospective analysis was conducted on 49 consecutive patients with HCC treated at Tokyo Metropolitan Komagome Hospital between May 2018 and October 2023. The patients were divided into two groups: the Atez/Bev group (21 patients) and the LEN group (28 patients).
Article Synopsis
- - The study focused on evaluating the safety of OP-724, an antifibrotic agent, in patients with cirrhosis due to HIV/HCV coinfection, who often face severe liver disease after receiving contaminated blood products.
- - Conducted as a phase I trial with five patients receiving the treatment, the primary goal was to track serious adverse events (SAEs), while secondary goals included monitoring other side effects and improvements in liver stiffness.
- - Results showed that OP-724 was well tolerated with no SAEs, although common side effects included fever and gastrointestinal issues; there were also signs of improved liver function, suggesting further research is warranted.
Hepatocellular carcinoma (HCC) usually occurs in settings of cirrhosis and chronic hepatitis B or C virus (HBV and HCV, respectively) infection; it is extremely rare in patients <40 years of age since viral- or alcohol-induced chronic hepatitis develops over a prolonged period. Juvenile HCC is mostly associated with persistent HBV infection; cases unrelated to HBV or HCV infection (non-B, non-C juvenile HCC) are sporadic and treated in the same way as classical HCC. A woman in her late 30s was diagnosed with HCC in a healthy liver; her imaging findings were typical of HCC with bone metastasis.
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