Publications by authors named "J Imai"
Article Synopsis
- A study investigated the impact of playing football on vitamin D levels and bone mineral density in middle-aged premenopausal women, comparing them to volleyball players and non-exercisers.
- Participants were evaluated based on bone density and vitamin D levels, revealing that both football and volleyball players had better outcomes than non-active individuals.
- Results showed that football players had the highest vitamin D levels and adequate bone density, suggesting that playing football may help prevent osteoporosis.
Article Synopsis
- The concept of Metabolic Associated Fatty Liver Disease (MAFLD) was introduced, focusing on metabolic risk factors like obesity and diabetes, which affect patients' prognosis better than the previously used Non-Alcoholic Fatty Liver Disease (NAFLD) criteria.
- A study involving 7,159 patients from Tokai University Hospital examined the impact of MAFLD versus NAFLD diagnostic criteria on disease progression and medication use over a 5-year period.
- Results showed that while 34.9% of participants had fatty liver, those diagnosed with MAFLD experienced a more considerable increase in starting new medications compared to those diagnosed only with NAFLD, indicating that MAFLD criteria could provide a clearer understanding of
Article Synopsis
- * Using mouse models treated with clodronate-liposomes to deplete macrophages, researchers found that Klebsiella pneumoniae can damage the intestinal lining and spread to the liver.
- * The findings highlight the crucial role of intestinal macrophages in preventing the translocation of commensal K. pneumoniae to the liver, suggesting that these mouse models can be useful for developing treatments to combat K. pneumoniae infections.
Aims/introduction: Insulin resistance syndrome and lipoatrophic diabetes are rare conditions characterized by the development of treatment-refractory diabetes with severe insulin resistance. We recently conducted a 24 week, multicenter, single-arm trial (EMPIRE-01) that demonstrated a certain level of effectiveness and safety of empagliflozin for these conditions. To evaluate treatment safety over a longer period, we have now performed an additional 28 week trial (EMPIRE-02) that followed on from EMPIRE-01.
View Article and Find Full Text PDFPossible etiological role of impaired endogenous double strand RNA editing in β-cells in type 1 diabetes.
J Diabetes Investig
September 2024
Proposed mechanisms by which disruption of endogenous dsRNA editing in β-cells leads to type 1 diabetes-like phenotypes in βAdarKO mice. Disruption of endogenous dsRNA editing in β-cells initiates IFN responses, thereby inducing pancreatic islet inflammation and β-cell dysfunction. Hyperglycemia induced by β-cell dysfunction further promotes islet inflammation, likely via increased dsRNA resulting from increased β-cell workload, thereby producing a vicious cycle.
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