Publications by authors named "J Iizuka"
Article Synopsis
- The study investigates sex differences in the outcomes of advanced renal cell carcinoma (RCC) patients treated with immune checkpoint inhibitors (ICIs) and their tumor-infiltrating immune cell profiles.
- Female patients exhibited shorter progression-free survival (PFS) compared to males when treated with first-line dual ICI combinations and nivolumab monotherapy, while no significant differences were found in other treatment groups.
- The lower effectiveness of ICIs in females might be attributed to differences in immune microenvironments, particularly the reduced presence of CD8+ T cells in female patients.
Article Synopsis
- This study aimed to evaluate the effectiveness of a mouthrinse with silver nanoparticles (AgNP) against polymicrobial biofilms in a lab setting.
- Polymicrobial biofilms were created on glass slips, treated with various solutions, including the mouthrinse with AgNP, chlorhexidine, and xylitol, then analyzed for viable cell counts and lactic acid levels.
- Results showed that the AgNP mouthrinse reduced viable cells in the biofilm similarly to or even better than 0.2% chlorhexidine, indicating its potential as an effective antimicrobial agent.
Background: Partial nephrectomy (PN) is strongly recommended as nephron-sparing surgery for T1 renal tumors. Although there have been some reports of robot-assisted PN (RAPN) for solitary allograft renal tumors, only a few cases of RAPN for multifocal allograft renal tumors have been reported. Herein, we report a case of a patient who underwent RAPN for multifocal allograft renal cell carcinoma (RCCs).
View Article and Find Full Text PDFPurpose: To clarify specific factors associated with surgical outcomes in robot-assisted partial nephrectomy (RAPN) that require extended warm ischemia time (WIT), which may have a negative impact, but cannot always be avoided.
Methods: We included 1,182 patients who had RAPN performed between January 2016 and December 2022 from a prospectively generated multi-institutional RAPN database, divided into normal WIT (nWIT) (≤ 20 min; 843 patients) and extended WIT (eWIT) (> 20 min; 339 patients) groups. Primary outcome measures were WIT and the Surface-Intermediate-Base (SIB) margin score, which contribute to postoperative trifecta achievement.
Background: Adrenal hemangiomas are extremely rare benign tumors that often need to be distinguished from malignancies. Adrenal tumors >4 cm in size are treated surgically because the possibility of malignancy cannot be ruled out. Traditionally, open surgery has been the mainstay of treatment; however, in recent years, robot-assisted surgery has been increasingly used for tumors of larger size and suspected malignancy.
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