The discovery of oligodendroglia cells by Rio-Hortega: his original articles. 1921.

Comment on: del Río-Hortega P. Glia with very few processes (oligodendroglia). Clin Neuropathol.

A modern reproducible method for the histologic grading of astrocytomas with statistical classification tools.

Objective: To investigate whether statistical classification tools can infer the correct World Health Organization (WHO) grade from standardized histologic features in astrocytomas and how these tools compare with GRADO-IGL, an earlier computer-assisted method.

Study Design: A total of 794 human brain astrocytomas were studied between January 1976 and June 2005. The presence of 50 histologic features was rated in 4 categories from 0 (not present) to 3 (abundant) by visual inspection of the sections under a microscope.

The clinico-surgico-pathological spectrum of myxopapillary ependymomas--report of four unusal cases and review of the literature.

According to the WHO grading system, myxopapillary ependymomas are assigned to WHO Grade I. However, the clinico-pathological spectrum might be very heterogenous. Herein, we report 4 cases exhibiting lumbar tumor masses, 1 causing muscular atrophy over a 30-year period, 3 displaying clinical history of persisting lumbar pain for only several weeks.

Causal probabilistic modeling for malignancy grading in pathology with explanations of dependency to the related histological features.

This work demonstrates that histological grading of brain tumors and astrocytomas can be accurately predicted and causally explained with the help of causal probabilistic models, also known as Bayesian networks (BN). Although created statistically, this allows individual identification of the grade of malignancy as an internal cause that has enabled the development of the histological features to their observed state. The BN models are built from data representing 794 cases of astrocytomas with their malignant grading and corresponding histological features.

Choroid plexus tumors differ from metastatic carcinomas by expression of the excitatory amino acid transporter-1.

Tumors of the choroid plexus (CPTs) are rare neoplasms of neuroectodermal origin usually arising in pediatric patients. However, CPT may occur at any age, and their distinction from metastatic carcinomas is often difficult in adult cases. Because CPTs frequently show focal glial differentiation, we now investigated 35 CPTs (19 males and 16 females 0.