Publications by authors named "J I Satoh"
Article Synopsis
- The study aimed to investigate the link between dietary potassium intake, sodium intake, and the incidence of cardiovascular disease (CVD) in Japanese patients with type 2 diabetes (T2DM).
- Analysis of 1,477 participants over a median follow-up of 7 years revealed no significant correlation between high potassium intake and CVD events.
- However, low potassium intake combined with high sodium intake was significantly associated with an increased risk of CVD in these individuals.
To what extent and how post-transcriptional dysregulation affects aging proteome remains unclear. Here, we provide proteomic data of whole-tissue lysates (WTL) and low-solubility protein-enriched fractions (LSF) of major tissues collected from mice of 6, 15, 24, and 30 months of age. Low-solubility proteins are preferentially affected by age and the analysis of LSF doubles the number of proteins identified to be differentially expressed with age.
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- *Methods*: Researchers analyzed mesenteric lymph nodes in lupus model mice to identify specific bacteria and their connection to autoantibody production using various laboratory techniques.
- *Results*: The study found that the bacterium Lactobacillus murinus was linked to heightened anti-dsDNA IgG levels in lupus mice, and its ABC transporter was identified as a cross-reactive antigen that could trigger antibody production in SLE.
Xenophagy, a type of selective autophagy, is a bactericidal membrane trafficking that targets cytosolic bacterial pathogens, but the membrane homeostatic system to cope with bacterial infection in xenophagy is not known. Here, we show that the endosomal sorting complexes required for transport (ESCRT) machinery is needed to maintain homeostasis of xenophagolysosomes damaged by a bacterial toxin, which is regulated through the TOM1L2-Rab41 pathway that recruits AAA-ATPase VPS4. We screened Rab GTPases and identified Rab41 as critical for maintaining the acidification of xenophagolysosomes.
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- The naked mole rat (NMR) lives a really long time and doesn't get many age-related diseases, which makes scientists curious about how it does that.
- Researchers looked at special cells from NMRs and compared them with cells from other animals to understand why NMRs are so healthy as they age.
- They found that a protein called CD44 plays a big role in helping NMRs deal with stress in their cells, which might help them live longer, even without needing another substance called hyaluronan (HA).