[Alagille syndrome and isolated persistent ductus arteriosus].

The clinical case of a 21-year-old patient diagnosed with a variant of intrahepatic biliary ductopenia or Alagille syndrome, a dominant inherited disorder associated with a chronic cholestatic syndrome and abnormalities in different organs and systems. The present article discusses the main clinical abnormalities found in this syndrome and we describe a persistent arterial ductus as an isolated cardiovascular manifestation not previously reported in association to this syndrome.

[Leukocytoclastic vasculitis as the form of presentation of hepatocarcinoma].

The clinical case of a 45-years old patient with previous diagnosis of alcoholic cirrhosis who was admitted to study the appearance of a picture consisting in erythematoviolescent lesions in the lower limbs and advanced renal failure is presented. Anatomopathologic study of the cutaneous lesions suggested the diagnosis of leukocytoclastic vasculitis. This fact was of special clinical interest on having taken into consideration the cytologic demonstration of hepatocarcinoma superimposed to the established chronic liver disease of the patient.